盐酸多奈哌齐治疗老年痴呆疗效观察

Donepezil Hydrochloride in The Treatment ofAlzheimer's Efficacy

目的:探讨给予老年痴呆症患者盐酸多奈哌齐治疗的临床疗效。方法:选取老年痴呆症患者80例,将患者随机分为两组(观察组与对照组)。给予对照组吡拉西坦片治疗;给予观察组盐酸多奈哌齐治疗。监测两组患者治疗前后的ADL(日常生活活动能力量表)及MMSE(简易智能精神状态检查量表)。结果:关于两组患者的ADL及MMSE评分,治疗前,无显著性差异,无统计学意义(P>0.05);治疗后,存在显著性差异,有统计学意义(P<0.05)。观察组的治疗总有效率高于对照组,P<0.05。结论:给予老年痴呆症患者盐酸多奈哌齐治疗,能够使患者的认知能力及生活自理能力有效提高,疗效显著,值得推广。

Objective： Observation donepezil HCL treatment of senile dementia effect.Methods： 80 cases of patients with Alzheimer’s disease,the patients were randomly divided into two groups.Give control group piracetam tablet treatment;Give the observation group donepezil HCL treatment.Before and after treatment,monitoring the ADL and MMSE of two groups.Results： About the ADL and MMSE score,Before treatment,no significant difference（P0.05）;After treatment,there exist significant differences（P0.05）.The total effective rate of observation group is higher than those in the control group,P0.05.Conclusion： Give senile dementia patients donepezil HCL treatment,the curative effect is distinct,worthy of promotion.