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护肝茶对小鼠酒精急性肝损伤模型的影响

Effect of Liver Protecting Tea on Alcohol Acute Liver Damage in Mice
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摘要 目的:研究护肝茶对50%乙醇所致急性肝损伤小鼠模型的影响。方法:50只小鼠随机分为5组,空白组,模型组,护肝茶高、中、低剂量组;护肝茶低、中、高剂量组灌胃给药30 d后,灌胃给予50%乙醇致急性肝损伤模型,观察护肝茶对急性肝损伤小鼠肝组织中还原型号谷胱甘肽(GSH)、甘油三酯(TG)、丙二醛(MDA)含量及肝组织病理的影响。结果:护肝茶高剂量组小鼠肝组织内的GSH含量明显提高,TG含量及肝脏脂肪变性程度明显降低,与模型组比较,差异均有统计学意义(P<0.01)。结论:高剂量的护肝茶对小鼠酒精急性肝损伤具有明显的保护作用。 Objective: To study the influence of Liver Protecting Tea on the model mouse of acute liver injury by alcohol (50%). Methods: 50 mice were divided into 5 group, blank group, model group, Liver Protecting Tea high dose, medium dose and low dose groups. The mice in Liver Protecting Tea high dose, medium dose and low dose groups were induced alcohol a- cute liver damage by alcohol (50%) after irrigation stomach of Liver Protecting for 30 days. And the GSH, TG, MDA and liv- er tissue pathology were observed. Results: Comparing with the model group, the levels of GSH rose, and the levels of TG and degree of hepatic steatosis reduced significantly, in Liver Protecting Tea high dose group (P〈0.01). Conclusion: Liver Pro- tecting Tea could protect the alcohol acute liver damage in mouse.
出处 《中医药导报》 2013年第9期69-71,共3页 Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词 护肝茶 酒精 急性肝损伤 小鼠 Liver Protecting Tea Alcohol Acute Liver Damage Mice
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