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系统性红斑狼疮患儿肿瘤坏死因子-α、抗ds-DNA抗体水平变化 被引量:4

Study on the levels of tumor necrosis factor-α and anti-ds-DNA antibody in children with systemic lupus erythe-matosus
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摘要 目的探讨系统性红斑狼疮(SLE)及狼疮性肾炎(LN)患儿血清肿瘤坏死因子-α(TNF-α)、抗ds-DNA抗体水平的变化及其与病情的相关性。方法选择67例SLE患儿(其中52例为LN患儿),以30例健康体检儿童为对照组,采用酶联免疫吸附法检测血清TNF-α水平,放射免疫法检测抗ds-DNA抗体水平。结果 SLE和LN患儿的血清TNF-α、抗dsDNA抗体水平均高于对照组,差异均有统计学意义(P均<0.01);SLE和LN患儿中活动期患儿的血清TNF-α、抗ds-DNA抗体水平均高于静止期患儿,差异均有统计学意义(P均<0.01);67例SLE患儿TNF-α与SLE疾病活动指数、抗ds-DNA水平均呈明显正相关(P<0.01)。结论 SLE及LN患儿血清TNF-α、抗ds-DNA抗体水平升高,且与病情活动性相关。 Objectives To investigate the changes and significance of serum tumor necrosis factor-or (TNF-α) and anti- ds-DNA antibody in systemic lupus erythematosus (SLE) and lupus nephritis (LN) in children. Methods Sixty-seven children with SLE among whom 52 children had LN were selected and 30 healthy children were selected as normal controls. The level of serum TNF-α was measured by enzyme-linked immunosorbent assay, and the anti-ds-DNA antibody level was measured by radioimmunoassay. Results The serum levels of TNF-α and anti-ds-DNA antibody were significantly higher in children with SLE or LN than those in healthy controls (P all 〈0.01). Furthermore, the serum levels of TNF-α and anti-ds-DNA antibody were significantly higher in active phase than in stationary phase of SLE and LN (P all 〈0.01). The serum TNF-α level was positively correlated with SLE disease activity index score and serum anti-ds-DNA level in 67 SLE patients (P〈0.05). Conclu- sions The serum levels of TNF-α and anti-ds-DNA antibody were increased in children with SLE and LN and were positivelycorrelated with disease activity.
出处 《临床儿科杂志》 CAS CSCD 北大核心 2013年第9期830-832,共3页 Journal of Clinical Pediatrics
关键词 系统性红斑狼疮 狼疮性肾炎 肿瘤坏死因子-Α 抗ds—DNA抗体 systemic lupus erythematosus lupus nephritis tumor necrosis factor-α anti-ds-DNA antibody
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