OSAHS患者手术治疗前后血清瘦素水平的变化

Changes of serum leptin levels in patients with obstructive sleep apnea-hypopnea syndrome before and after treatment of surgery

目的:探讨OSAHS患者手术治疗前后血清瘦素水平的变化与临床意义。方法:根据术前、术后6个月PSG将患者分为治疗有效组(44例)和治疗无效组(13例),治疗有效组再根据术前和术后的BMI分为体重下降组(25例)和体重无明显下降组(19例)。用放射免疫法测定各组术前和术后6个月血清瘦素水平。结果:治疗无效组13例术后6个月血清瘦素水平(9.1±2.6μg/L)和治疗前(9.3±2.3μg/L)相比,差异无统计学意义。25例BMI下降幅度≥5%的患者术后6个月血清瘦素水平(7.15±1.23μg/L)和治疗前(12.79±2.98μg/L)相比,差异有统计学意义(P<0.01);19例BMI下降幅度<5%的患者术后6个月血清瘦素水平(6.85±2.03μg/L)和治疗前(11.83±2.43μg/L)相比,差异有统计学意义(P<0.01)。无论是术前还是术后6个月,瘦素水平与AHI均呈正相关(r=0.69,P<0.01)。结论:OSAHS患者血清瘦素水平增高,治疗有效者瘦素水平下降。血清瘦素水平可以反映OSAHS的严重程度。

Objective：To investigate the change of serum leptin levels in patients with obstructive sleep apneahypopnea syndrome（OSAHS） before and after surgery. Method：The cases were divided into effective（n= 44） and non-effective（n= 13） groups according to PSG. The effective cases were divided into decreased（≥5% ,n=25）and non-decreased（〈 5 %, n = 19） BMI. The level of serum leptin was detected by radioimmunoassay. Result ： The level of serum leptin after treatment（9. 1±2.6 μg/L） was as high as before treatment（9.3±2.3 μg/L）in 13 non-effective cases. The level of serum leptin after treatment（7. 15 ±1. 23 μg/L） was significantly decreased than before treatment（12.79 ±2.98 μg/L）in 25 cases of decreased BMI（≥5%T）. The level of serum leptin after treatment （7.15±1.23 μg/L） was significantly decreased than before treatment（12.79±2.98 μg/L）in 19 cases of non-decreased BMI（〈5%）. Leptin level of all cases showed a positive correlation with AHI（P〈0.01）. Conclusion：The level of serum leptin in patients with OSAHS are increased. The serum leptin level of effective patients with OSAHS after treatment was significantly decreased. The level of serum leptin reflects the degree of AHI in patients with OSAHS.