明目颗粒质量标准研究

Study on quality standard of Mingmu Granule

目的研究明目颗粒的质量控制标准。方法采用薄层色谱法对制剂中的苍术、化橘红、防风进行定性鉴别，采用高效液相色谱法测定芍药苷的含量。结果苍术、化橘红、防风的薄层色谱鉴别专属性强；芍药苷在10．92～109．2μg 范围内有良好的线性关系，r ＝10．000，平均加样回收率为970．3％，RDS为12．％。结论该方法简便、准确、重现性好，可作为该颗粒剂的质量控制标准。

Objective To establish the quality standards of Mingmu Granule . Methods The identification of atractylodis rhizoma , citri exocarpium pubrum , saposhnikoviae radix were carried out by TLC . The content of Paeoniflorin was determinded by HPLC . Results Atractylodis rhizoma , citri exocarpium pubrum , and saposhnikoviae radix could be detected by TLC . A good linearity of Paeoniflorin was in the range of 1 .092 ~10 .92 μg（ r = 1 .0000） and the average recovery was 97 .03% ,RDS was 1 .2% （ n= 5） .Conclusion This method is simple , accurate and has good reproducibility and can be used for the quality control of Mingmu Granule .