摘要
目的:探索β-环糊精(β-CD)包合冰片的最佳工艺,并进行工艺验证和放大。方法:以包合率、包合物收率、包合物中的冰片含量为评价指标,采用正交试验设计对该制备方法进行工艺优化,通过验证试验对最佳工艺进行验证,并将最佳工艺进行等比放大。结果:L9(34)正交试验优选出包合物工艺为:冰片与β-CD投料比为1∶4,包合温度为40℃,包合时间为4h。IR和1H-NMR分析证明包合物形成。验证试验证明该工艺为最佳工艺,将工艺放大后结果稳定。结论:以饱和水溶液法制备冰片β-CD包合物,工艺简单,包合物收率和包合率高,包合工艺稳定可放大。
Objective: To optimize the preparation technology of borneol-β-cyclodextrin inclusion complex, then verify and scale up the technology. Methods: Preparation process of inclusion complex was optimized by L9(34) orthogonal design, as the inclusion rate of borneol, yield of inclusion complex and the content of borneol were determined. Verifying and enlarged experiments were also conducted. Results: The best condition to prepare inclusion complex was as follows. The weight ratio between borneol and β-CD was 1:4, the temperature was 40℃ and the reaction time was 4h. The formation of inclusion complex was proved by IR and 1H-NMR. The optimized preparation condition was proved effective and stable by verifying and enlarged experiments. Conclusion: Saturated solution method is simple for preparing borneol-β-cyclodextrin inclusion complex. The inclusion rate of borneol and the yield of inclusion compound are higher. It can be used for the production in industry.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2013年第10期3115-3117,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
科技人员服务企业行动资助项目(No.2009GJA10033)~~
关键词
冰片
Β-环糊精
包合物
正交设计
放大实验
Borneol
β-Cyclodextrin
Inclusion complex
Orthogonal design
Enlarged experiment