趋化因子结合蛋白在肿瘤中的作用及临床意义

Role and significance of chemokine-binding proteins in tumor

趋化因子及其受体与肿瘤的发生、发展过程密切相关,针对趋化因子受体的抗体及小分子拮抗剂可能具有抗肿瘤作用。然而肿瘤微环境中的趋化因子为数众多,相互关系极其复杂,有必要确立针对趋化因子网络的多靶点调控策略。DARC、D6、CCX-CKR、Evasins、US28等趋化因子结合蛋白(CKBP)可以同时捕获肿瘤微环境中的多种促肿瘤性趋化因子,管控肿瘤细胞的生物学行为,已经或正在呈现出广阔的应用前景。

Chemokines and chemokine receptors are associated with the growth, metastasis of tumor cells. Antibodies or small moleculer antagonists against for ehemokine receptors should be used as anti-cancer drugs. However, the re- cent failures in the clinical trials of some single target antagonists suggest that chemokine network in tumor mieroenvi- ronment is very complicated. Obviously, multi-targets regulation strategy for chemokine network is indispensable. Chemokine-binding proteins （CKBP）, including DARC, D6 and CCX-CKR, Evasins from ticks, US28 from virus, may control the biological behavior of tumor cells, by sequestrating pro-tumor ehemokines simultaneously.