摘要
目的比较鼻咽癌每周7次连续加速分割逆向调强放疗与常规逆向调强放疗的近期疗效及毒副作用。方法采用单双月分组方法将83例经病理学证实的初治鼻咽癌患者分至每周7次连续加速分割逆向调强放疗(continuous accelerated intensity modulated radiation therapy,CAIMRT)组及常规分割逆向调强放疗(intensity modulated radiation therapy,IMRT)组。总剂量70 Gy,分割剂量每次2 Gy。结果两组患者均顺利完成治疗,两组完全缓解率(complete response,CR)分别为86.8%及80%,统计学比较无明显差异(P>0.05)。CAIMRT组与IMRT组比较,急性皮肤和黏膜反应出现时间提前,差异具有统计学意义(P<0.05);总住院时间有所缩短,差异具有统计学意义(P<0.01)。结论鼻咽癌患者采用每周7次连续加速分割逆向调强放疗,患者能够耐受,肿瘤近期局部控制率好。
Objective To evaluate the toxicity and recent efficacy of 7-times-per-week continuous accelerated inten- sity modulated radiation therapy (CAIMRT) compared with conventional intensity modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC). Method 83 patients with pathologically confirmed NPC were randomized into CAIM- RT group and IMRT group by odd-/even-nmnbered month, with total dose being 70 Gy and fraction of 2.0 Gy. Result All patients had successfully completed therapy. The local complete response rates of CAIMRT and IMRT were 86. 8% and 80%, respectively. While the acute skin and mucosal toxicity reaction time in CAIMRT group had obviously advanced compared with IMRT group ( P 〈 0. 05 ), and the total hospitalization time had significantly shortened ( P 〈 0. 01 ) as well. Conclusion The 7-times-per-week continuous accelerated intensity modulated radiation therapy is well tolerated, with good recent local control.
出处
《癌症进展》
2013年第5期480-484,共5页
Oncology Progress
基金
徐州市科技局项目(xz201023)
关键词
连续加速放疗
鼻咽癌
调强放射治疗
毒副作用
continuous aceeIerated irradiation
nasopharyngeal carcinoma
intensity modulated radiation therapy
toxicity effects