蓝萼香茶菜增加小鼠心肌血流灌注量的药效动力学

Pharmacodynamic Studies on Rabdosia japonica with Myocardial Blood Flow Perfusion in Mice

目的探讨蓝萼香茶菜药效动力学。方法以小鼠心肌血流灌注量为指标进行测定。结果蓝萼香茶菜在小鼠体内并非呈简单的房室模型,其最低起效剂量为生药0.7899 g.kg-1,效应达峰时间约为1 h,效应作用期长达6 h以上。结论蓝萼香茶菜体内具有吸收快,消除慢和作用维持时间长等特点。

Objective To investigate the pharmacodynamics of Rabdosia japonica.Methods The myocardial blood flow perfusion in mice was measured.Results There was on simple compartment model when Rabdosia japonica was administrated orally in the mouse.The minimal effective dose was 0.7899 g · kg-1.The duration and peak time of effective action was 6 h and 1h respectively.Conclusion Rabdosia japonica can be characterized by fast absorption,slow elimination and a long effective action time.