重复控制性卵巢刺激(COS)-IVF/ICSI治疗对卵巢储备功能及反应性的影响

Effect of Repeated COS-IVF/ICSI Treatment on Ovarian Reaction and Ovarian Reserve

目的:探讨年轻女性在接受反复控制性卵巢刺激(COS)-IVF/ICSI治疗对卵巢储备功能及其反应性的变化。方法:回顾性分析连续3次接受COS-IVF/ICSI-ET治疗周期的<35周岁的不孕症患者,分析比较其实验室指标和临床结局。结果:共纳入129例不孕症患者的387个周期。患者3个COS-IVF/ICSI治疗周期间月经第3日的基础卵泡刺激素(basal follicle-stimulating hormone,bFSH)、窦卵泡计数(antral follicle count,AFC)、促排卵天数、hCG注射日E2峰值、获卵数、正常受精率及优质胚胎率均无统计学差异(P>0.05);第2次和第3次治疗周期使用促性腺激素(gonadotropin,Gn)剂量明显高于第1次治疗,差异具有统计学意义(P<0.05)。结论:<35周岁重复COS-IVF/ICSI周期对卵巢储备功能无影响,对其卵巢反应性有一定影响。

Objective： To investigate the possible effect of repeated control ovarian stimulation （COS）-IVF/ ICSI treatment on ovarian reserve and reaction. Methods： Patients who were underwent three IVF/ICSI treatments and with female age 〈35 years old were retrospectively analyzed. The effect of repeated COS-1VF/ICSI treatment on the basal follicle-stimulating hormone （bFSH）, the antral follicle count （AFC）, the dosage required of gonadotropin （Gn）, the number of oocytes retrieved, the fertilization rate and the high-quality embryo rate were compared. Results： A total of 129 infertile couples （387 cycles） were included. The dosage of Gn used was significantly higher in the second and third cycles than in the first cycle （P〈0.05）. The results showed no statistically significant differences in all three cycles （P〉0.05） in terms of the number of oocytes retrieved, bFSH, AFC, the fertilization rate and the high-quality embryo rate. Conclusion： Repeated COS-IVF/ICSI treatment has no significantly adverse impact on the ovarian reserve of women aged 〈35 years old, but ovarian reaction is influenced in some degree.