脂肪细胞因子基因多态性与T2DM关联性Meta分析

Association of adipocytokine gene polymorphisms with type 2 diabetes mellitus: a meta-analysis

目的 应用Meta分析对脂肪细胞因子中的肿瘤坏死因子α、瘦素受体和脂联素基因多态性与2型糖尿病（T2DM）关联性进行综合评价。方法 应用哈代-温伯格平衡对入选文献的基因型进行遗传平衡性检验,根据异质性检验结果选用固定或随机效应模型,采用Begg＇s和Egger＇s法对发表偏倚进行量化检测,应用RevMan 5.1软件进行Meta分析。结果 共50篇文献符合条件纳入研究,纳入文献无明显发表偏倚;瘦素受体 SNP-668A〉G与T2DM的关联性差异无统计学意义;而肿瘤坏死因子α SNP-308G〉A A对G等位基因的OR（95%CI）=1.38（1.11-1.71）,GA＋AA对GG基因型的OR（95%CI）=1.26（1.05-1.51）,差异均有统计学意义（P〈0.05）;脂联素SNP＋45T〉G G对T等位基因的OR（95%CI）=1.17（1.03-1.33）,GG＋TG对TT基因型的OR（95%CI）=1.16（1.01-1.34）,差异均有统计学意义（P〈0.05）。结论 瘦素受体SNP-668A〉G基因多态性与T2DM无明显关联,而肿瘤坏死因子α SNP-308G〉A和脂联素SNP＋45T〉G可能是T2DM的危险因素。

Objective To evaluate the associations of gene polymorphisms in adipocytokines tumor necrosis factor α（TNFα）,leptin receptor and adiponectin with type 2 diabetes mellitus（T2DM） using method of meta-analysis.Methods Hardy-Weinberg equilibrium（HWE） test was used to check genetic equilibrium between genotypes for the selected literature.A fixed or random effect model was used on the basis of heterogeneity.Publication bias was quantified and examined with the Begg＇s and Egger＇s method.The meta-analysis was performed with Review Manager 5.1 Software.ResultsFifty reports met the inclusion criteria for this meta-analysis.No significant publication bias was identified in the selected literature.There were no statistical significant results found regarding the association of leptin receptor（LEPR） single nucleotide polymorphism（SNP）-668A〉G and T2DM.However,for TNFα SNP-308G〉A,the odds ratioand 95% confidence interval for A vs G allele and GA＋AA vs GG were 1.38（1.11-1.71） and 1.26（1.05-1.51）,respectively,with statistical significances.For adiponectin SNP＋45T〉G,the OR（95%CI） for G vs T allele and GG＋TG vs TT was 1.17（1.03-1.33） and 1.16（1.01-1.34）.Conclusion There is no significant association between the LEPR SNP-668A〉G polymorphisms and risk for T2DM.However,TNFα SNP-308G〉A and adiponectin SNP＋45T〉G might be risk factors for type 2 diabetes mellitus.