氨茶碱注射液与5种常用输液的配伍稳定性考察

Compatible Stability of Aminophylline Injection with 5 Kinds of Commonly Used Infusions

目的:考察氨茶碱注射液与5种常用输液配伍的稳定性。方法:采用高效液相色谱法测定氨茶碱注射液与0.9%氯化钠注射液、5%葡萄糖注射液、10%葡萄糖注射液、葡萄糖氯化钠注射液、复方氯化钠注射液配伍后茶碱的含量,采用pH测定仪测定其酸碱度变化。结果:25℃下,24 h内混合溶液的性状、pH值、含量均无显著性改变。结论:氨茶碱注射液与5种常用输液配伍在25℃下24 h内稳定。

OBJECTIVE： To investigate compatible stability of Aminophylline injection with 5 kinds of commonly used infu- sions. METHODS： The content changes of Aminophylline injection were determined by HPLC after combined with 0.9% Sodium chloride injection, 5% Glucose injection, 10% Glucose injection, Glucose and sodium chloride injection and Compound sodium chloride injection, pH detector was used to determine the changes of pH value. RESULTS： At 25℃, there was no significant change in the property, pH value and content of mixture within 24 hours. CONCLUSIONS： At 25 ℃, Aminophylline injection combined with 5 kinds of commonly used infusions are stable within 24 hours.