布拉氏酵母菌散剂预防小儿抗生素相关性腹泻的临床观察

Effect of Saccharomyces Bouiardii on Prevention of Antibiotic-associated Diarrhea in Children

目的:探讨布拉氏酵母菌散剂预防小儿支气管炎及肺炎抗生素相关性腹泻(antibiotic-associated diarrhea,AAD)的作用。方法:120例患有支气管炎和肺炎住院儿童随机分成两组。治疗组60例,自开始使用抗生素起,即口服布拉氏酵母菌散剂250 mg/次,2次/d;对照组60例,仅使用抗生素;出现腹泻后两组患儿均加用蒙脱石散剂和补液治疗,比较两组患儿的抗生素相关性腹泻率。结果:治疗组4例(6.7%)患儿发生AAD,对照组14例(23.3%)患儿发生AAD,两组患儿AAD发生率比较差异有统计学意义(P<0.05)。治疗组患儿腹泻持续时间(2.0±1.5)d,较对照组的(4.0±2.5)d短,差异有统计学意义(P<0.05)。结论:布拉氏酵母菌能有效预防小儿抗生素相关性腹泻。

Objective：To explore the preventive efficacy of saccharomyces boulardii for children with bronchitis and pneumonia on antibiotic-associated diarrhea.Method：120 hospitalized children diagnosed with bronchitis or pneumonia were randomly divided into two groups.60 children in treatment group received standard antibiotics and saccharomyces boulardii for 7-10 days.The control group received standard antibiotics only.The incidence of antibiotic-associated diarrhea was compared in two groups.Result：4 cases（6.7%） AAD in treatment group were less than 14 cases（23.3%） AAD in control group（P〈0.05）.The diarrhea duration in treatment group was significantly shorter than that in placebo group（P〈0.05）.Conclusion：The prophylactic use of saccharomyces boulardii together with antibiotics can effectively prevention the AAD.