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TGF-β复合BMP盖髓的组织学观察 被引量:5

Histological observation on transforming growth factor-β compounded with bone morphogenetic protein as a pulp capping material
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摘要 目的 :用 β转化生长因子复合骨形成蛋白 (TGF - β/BMP)覆盖狗暴露牙髓 ,观察TGF - β/BMP的盖髓效果。方法 :用活体狗牙作直接盖髓实验 ,并用组织学方法评价盖髓效果。结果 :术后 8周 ,TGF - β/BMP能够诱导牙髓成纤维细胞、内皮细胞增殖并抑制炎症反应 ,提高牙髓修复能力 ,有完整的牙本质桥形成。结论 :TGF - AIM: Observation of the effects of transforming growth factor-β compounded with bone morphogenetic protein (TGF-β/BMP) on the exposed pulp of dogs. METHODS: The teeth of dogs were used for direct pulp capping experiment and the results were evaluated histopathologically. RESULTS: Eight weeks postoperatively TGF-β/BMP was able to induce the proliferations of the pulp cells (fibroblasts)and endothelial cell, inhibit the inflammatory reaction of pulp, and possessed the ability to enhance the pulp repairing, complete dentin bridge was induced. CONCLUSION:TGF-β/BMP can promote the regeneration of dog's pulp tissue. [
出处 《牙体牙髓牙周病学杂志》 CAS 2000年第6期321-323,共3页 Chinese Journal of Conservative Dentistry
基金 沈阳军区资助项目
关键词 盖髓剂 转化生长因子Β 骨形成蛋白 dog pulp capping transforming growth factor β bone morphogenetic prot
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参考文献4

  • 1Hock JM,Canalis E,Centrella M,et al.Transforming growth factor βstimulates bone metrix apposition and bone cell replication in cultured fetal rat calvariae[].The Journal of Endocrinology.1990
  • 2Sumner DR,Turner TM,Purchio AF,et al.Enhancement of ingrowth by TGF-β[].Journal of Bone and Joint Surgery British Volume.1995
  • 3Nielson HM,Andreassen TT,Ledet T,et al.Local injection of TGF-βincreases the strength of tibial fractures in the rat[].Acta Orthopaedica Scandinavica.1994
  • 4Chenu C,Pfeilschifter J,Mundy GR,et al.Transforming growth factor βinhibits formation of osteoclasts- like cells in long term human marrow cultures[].Proceedings of the National Academy of Sciences of the United States of America.1998

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