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肝脏X受体在阿尔茨海默病中的作用及其机制研究进展

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摘要 肝脏x受体是（Liver X receptors，LXR）属于核受体超家族中的一类转录因子，是与脂类代谢有关的核受体，兼具调节细胞免疫和胆固醇代谢的作用，包括LXRcL（NRlH3）和LxRB（NRlH2）两种亚型，LXRct主要分布在肝脏等与脂类代谢相关的器官，而L）（RB在全身各组织均有广泛表达，在中枢神经系统分布较为丰富。有研究发现内源性的LXR信号会影响阿尔茨海默氏病（Alzheimer’s disease，AD）相关的病理改变的形成。
作者 黄伟 徐培 陈军花 赵美娜 范晓棠 徐海伟
机构地区 第三军医大学组织胚胎学教研室 第三军医大学西南医院眼科
出处 《神经解剖学杂志》 CAS CSCD 北大核心 2013年第6期701-704,共4页 Chinese Journal of Neuroanatomy
基金 国家自然科学基金(31071299 30970947) 重庆市留学回国人员启动基金(cstc2011jjzt0137)
关键词 LXR AD 胆固醇 胶质细胞 神经发生
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献42

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二级参考文献16

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神经解剖学杂志
2013年 第6期

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