Carbonic Anhydrase IX在胃癌中的表达及对胃癌术后复发的影响

Significance of carbonic anhydrase IX (CAIX) expression in gastric carcinoma and the influence on the recurrence of gastric cancer after operation

目的 探讨CAⅨ（Carbonic Anhydrase IX）在胃癌组织中的表达以及对胃癌术后复发的影响.方法 采用免疫组化染色法检测CAIX在56例术后胃癌病人组织中的表达,比较不同分期的胃癌组织中CAIX表达的差异以及对术后胃癌病人术后复发率的影响.结果 56例胃癌组织切片中CAIX阳性率为85.7％;在Ⅰ～Ⅳ期的阳性率分别为40.0％、66.7％、96.8％、100％,不同分期胃癌组织中CAIX阳性表达比较有显著差异（P＜0.05）;CAIX阳性者手术后1～3年的累计肿瘤复发率分别为35.4％、54.2％、66.7％,CAIX阴性者手术后1～3年的累计肿瘤复发率分别为0％、12.5％、25％,两组手术后1～3年的累计肿瘤复发率比较有显著差异（P＜0.05）.结论 CAIX在胃癌组织中的表达随着胃癌分期增加而增加,CAⅨ阳性者预后差且更容易出现术后的复发.

Objective To explore the Carbonic Anhydrase IX （CAIX） expression in gastric cancer tis- sue and the effect on the gastric cancer recurrence after surgery. Methods Immunohistochemical staining was used to detect CAIX in 56 cases of postoperative patients with gastric cancers, and comparison of CAIX expression in different stages of gastric cancer tissue was made and the postoperative recurrence of gastric cancer patients in relation with CAIX expression was onvestigated. Results In 56 cases of gastric cancer tissue biopsies CAIX positive rate was 85.7%, in phase I, II, III, IV positive rate were 40. 0%, 66.7%, 96.8% and 100% respectively. CAIX-positive expression in different stages of gas- tric cancer had significant difference （P 〈 0.05）. The patients of CAIX positive 1 - year 2 - year, 3 - year after surgery with the cumulative recurrence rate was 35.4%, 54.2 %, 66.7%, respectivelyIn CAIX-negative patients 1 year 2 - year, and 3 - year after surgery, the cumulative recurrence rates were 0 %, 12.5% , and 25%. The 1 -3 years of cumulative recurrence rates in the two groups after surgery were significantly different （ P 〈 0.05 ）. Conclusion Expression of CAIX in gastric cancer tis- sue increased with the increase of the staging of gastric cancer, and CAIX positive was a poor prognostic factor and more prone to recurrence.