溃疡性结肠炎患者血清IL-23、C-反应蛋白含量及临床意义

Expressions of IL- 23 and CRP Inflamed Mucosa of Patients with Ulcerative Colitis and Their Clinical Significance

目的探讨IL-23及C-反应蛋白(CRP)在溃疡性结肠炎患者中的表达情况及临床意义。方法选取40例溃疡性结肠炎患者(轻度、中度、重度活动期分别为4例、12例和14例,缓解期10例)为UC组,另取16名健康志愿者作为正常对照组。按照中国炎症性肠病诊断治疗规范的共识意见,对40例UC患者进行临床特征分析,采用ELISA法检测各组血清IL-23及CRP含量,比较二者在二组中的表达,分析IL-23及CRP与疾病活动程度的相关性。结果 UC患者病变范围以全结肠和左半结肠(30%,37.5%)为主,中度、重度(37.5%,35.0%)多见,有肠外表现者占5%,存在病变累及范围越广、病情越严重的趋势。轻度、中度、重度活动期UC患者IL-23及CRP表达量依次增高,组间两两比较差异均有统计学意义(P<0.05),且均显著高于正常对照组(P<0.05);缓解期患者血清IL-23及CRP水平与正常对照组相比差异无统计学意义(P>0.05)。结论 IL-23及CRP在UC的发生、发展中起重要作用,两者的表达水平可反映UC疾病活动度。

Objective To investigate the expression and clinical significance of IL-23 and CRP in patients with ulcerative colitis. Methods 40 cases of UC patients （light, heaw, in active stage were 4 cases, 12 cases and 14 cases, 10 cases in remission period） were chosen as ulcerative colitis group, another 16 healthy volunteers as normal control group. According to the inflammatory bowel disease diagnosis and treatment standard in China, analysis was conducted on the clinical features of the 40 cases of UC patients, ELISA method was used to detect serum IL-23 and CRP content of the two groups, and their expressions were compared, followed by the a- nalysis of relevance of IL-23 and CRP and disease activity. Results Patients with UC lesions mainly suffered from total colectomy and left colon （30%,37.5%）, moderate and severe cases being 37.5% and 35% respectively, extra intestinal manifestations accounting for 5%, along with the tendency that the wider the lesions were, the illness became more serious. Serum contents of IL-23 and CRP increased with the clinical symptoms. Serum contents of IL-23 and CRP in severe patients were higher than those of mild and moderate patients significantly, and serum contents of IL-23 and CRP in moderate patients were higher than those of mild patients significantly.But there was no significant difference between patients at remission stage and those in normal group. Conclusion IL-23 and CRP play an important role in the occurrence and progression of UC, the expression level of UC can reflect the severity of disease.