组织工程化软骨修复运动性关节软骨损伤

Tissue-engineered cartilage repair for sports-induced articular cartilage injury

背景:组织工程学的出现及发展为解决运动性关节软骨缺损、重建关节功能提供了新思路,使软骨组织缺损的完全再生成为可能。目的:了解组织工程研究的基本原理,分析组织工程化软骨构建的影响因素,探究组织工程化软骨修复运动性关节软骨损伤的可行性。方法:通过检索近年来关于组织工程化软骨的构建及应用的研究成果及动物实验相关文献,分析应用组织工程学方法在体内形成新生软骨组织的可能性,着重论述组织工程化软骨构建及在软骨损伤和修复研究中的应用,为组织工程化软骨修复运动性软骨缺损提供理论基础。结果与结论:种子细胞、支架材料和体外培养环境,构成了软骨组织工程学注重的两个要素,二者组成了一个相互促进相互制约的整体,在组织工程化软骨修复运动性关节软骨损伤过程中,注重三者的恰当配置应是治疗中着重解决的关键问题。

BACKGROUND： The emergence and development of tissue engineering technology provides a new idea for reconstruction of joint functions after sports-induced articular cartilage injuries, and realizes complete regeneration of cartilage tissue. OBJECTIVE： To understand the basic principles of tissue engineering research, to analyze factors influencing tissue-engineered cartilage construction, and to explore the feasibility of tissue-engineered cartilage repair for sports-induced articular cartilage injury. METHODS： Through the retrieval of literatures on the construction and application of tissue-engineered cartilage, we analyzed the feasibility of new cartilage formation in vivo using tissue engineering technology, focused on tissue-engineered cartilage construction and its application in cartilage injury and repair, thereby providing a theoretical basis for tissue-engineered cartilage repair of sports-induced cartilage injuries. RESULTS AND CONCLUSION： Seed cells, scaffolds and in vitro culture environment constitute two elements of cartilage tissue engineering, which, as a whole, promote and restrict each other. The proper configuration of seed cells, scaffolds and in vitro culture environment is the key issue to be solved in the treatment of sports-induced cartilage injuries.