摘要
目的 :观察解酒护肝饮对酒精性肝损伤大鼠血清和肝组织MDA、GSH的影响 ,验证其对酒精性肝损伤防治作用及药效。方法 :以益肝灵、葛花解酲汤为对照 ,采用白酒灌胃造模 ,分别预防给药和治疗给药后检测各组大鼠血清和肝组织MDA、GSH含量。结果 :预防给药结果表明 ,解酒护肝饮高剂量降低模型大鼠血清及肝组织MDA作用与葛花解酲汤、益肝灵相当 ,但阻止GSH的耗竭 ,提高GSH活性作用优于两对照药。高、低剂量具有量效关系。治疗给药结果表明 ,解酒护肝饮高、低剂量均能降低模型大鼠血清及肝组织MDA含量 ,阻止GSH的耗竭 ,提高GSH活性 ,并具有量效关系。结论 :解酒护肝饮能够通过降低血清和肝内MDA含量 ,抑制过氧化反应 ,减轻MDA对肌体的损伤 ;同时提高GSH活性 ,增加GSH的含量 ,对抗过氧化反应 ,可有效防治酒精性肝损伤 ,且疗效优于益肝灵与葛花解酲汤。
Objective:T observe the effect of anti-alcohol&liver-protection drink on blood serum and liver tissue MDA and GSH of rat with alcoholic liver injury and testify its prevention and treatment funciton as well as drug effect.Method:The rat model of alcoholic liver injury was duplicated by filling the stomach with spirits and was given prevention medicine and treatment medicine respectively,using Yiganling and pueravia flower decoction as control gvoup.Then the rat′s MDA and GSH of blood serum and liver tissue in each group were determined.Result:The prevention medicine suggested that the high-dose anti-alcohol&liver-protection drink had similar fumction with the pueravia flower decoction and Yiganling in reducing the model rat′s MDA and GSH of blood serum and liver tissue,but had more significant function in stopping the exhaustion of GSH and increasing the GSH activity than the two control groups.The high-low dose had dose-effect relationship.The treatment medicine indicated that both the high or low dose of anti-alcohol&liver-protection drink could reduce the model rat′s blood serum and liver tissue MDA,stop the exhaustion of GSH,increase the GSH activity and with dose-sffect relationship.Conclusion:The anti-alcohol&liver-protection drink coudl inhibit the preoxidation and reduce MDA′s injury to organism by means of decreasing the MDA content of blood serum and liver tissue;In addition,it could also enhance GSH activity,increase the GSH content,inhibit the peroxidation,prevent alcoholic liver injury with more significant effect than Yiganling and pueravia flower decoction.
出处
《河北中医药学报》
2000年第4期1-5,14,共6页
Journal of Hebei Traditional Chinese Medicine and Pharmacology
基金
河北省卫生厅资助项目!990 2 5号
关键词
酒精性肝损伤
解酒护肝饮
中医药疗法
预防
alcoholic liver injury
anti-alcohol&liver-protection drink
rat
prevention
treatment
MDA
GSH