进展期胃癌根治术后早期复发的相关因素分析及治疗

Analysis of factors related to early recurrence of advanced gastric cancer after radical resection and treatment

目的:研究进展期胃癌根治术后早期复发的相关因素以及治疗方式。方法:2010年1月—2012年1月行胃癌根治术的进展期胃癌患者97例,根据患者1年内复发情况分为早期复发组(51例)和无复发组(46例),进行单因素以及非条件Logistic回归分析,研究影响进展期胃癌根治术后早期复发的相关因素。结果:经单因素分析显示,瘤体直径、Borrmann分型、Lauren分型、TNM分期、N分期、T分期、术后化疗及新辅助化疗均是进展期胃癌根治术后早期复发的影响因素(P<0.05);经多因素分析显示,N分期以及TNM分期是影响进展期胃癌根治术后早期复发的主要独立危险因素,而新辅助化疗则是其独立保护因素(P<0.05)。结论:N分期以及TNM分期是进展期胃癌根治术后早期复发的主要独立危险因素,积极实施新辅助化疗以及手术治疗,可有效降低早期复发率,延长患者的生存期。

Objective： To study the advanced gastric cancer after radical resection of factors related to early recurrence and treatment methods. Methods： From 2010 January to 2012 January, radical resection of gastric cancer in patients with advanced gastric cancer in 97 cases, according to the recurrence patients 1 years divided into early recurrence group （51 cases） and non recurrent group （46 cases）, regression analysis of single factor and non conditional Logistic, effect of radical surgery for advanced gastric cancer after the factors related to early recurrence. Results： The sin- gle factor analysis showed that, the diameter of tumor, Lauren type, Borrmann type, TNM staging, N staging, T staging and postoperative adjuvant chemotherapy were main factors of early recurrence after radical resection of advanced gastric cancer; multivariate analysis showed that, N staging and TNM staging was a major independent risk of early recurrence in advanced gastric cancer after radi- cal operation factors. Co^r~lusio~ N staging and TNM is a major independent risk factors for early recurrence of advanced gastric cancer after radical resection, and actively implement the neoadjuvant chemotherapy and operation treatment, can effectively reduce the relapse rate, prolong the survival time of patients.