摘要
目的 :研究含大剂量表柔比星的联合化疗方案治疗晚期乳腺癌的疗效和毒副反应。方法 :16例晚期乳腺癌患者接受CEF方案化疗 :环磷酰胺 (CTX) 6 0 0mg/m2 ,表柔比星 (EPI) 10 0mg/m2 ,氟尿嘧啶 (5 FU) 5 0 0mg/m2 ,每 2 1天重复。每个病例至少应用 2疗程。结果 :2例获CR ,9例获PR ,总有效率 6 8 8% (11/ 16 )。主要的毒性反应为白细胞下降 ,恶心和呕吐、脱发 ,均多为Ⅰ、Ⅱ级 ,患者可以耐受。结论 :含大剂量表柔比星的联合化疗方案对晚期乳腺癌安全有效 。
Purpose:To study the efficacy and the toxic side effects of high dose epirubicin containing combination regimen in the treatment of advanced breast cancer. Methods:16 patients with advanced breast cancer were treated with epirubicin (EPI) 100 mg/m 2,CTX 600 mg/m 2,5 FU 500 mg/m 2,every 21 days,Each patient was given at least 2 cycles. Results:There were 2 CR and 9 PR, the overall response rate was 68.8% (11/16). Main side effects were grade Ⅰ—Ⅱ leucopenia, nausea and vomitting, alopecia.Conclusions:This study confirmed that combination chemotherapy with high dose epirubicin is a safe and effective regimen for patients with advanced breast cancer and is worthy of further clinical trial.
出处
《中国癌症杂志》
CAS
CSCD
2000年第6期527-528,共2页
China Oncology
关键词
乳腺癌
表柔比星
联合化疗
大剂量
breast cancer
epirubicin
combination chemotherapy