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两组大剂量化疗方案治疗晚期乳腺癌病例的比较 被引量:2

Comparative Study of Two Different High-dose Chemotherapy Protocols for Advanced Breast Cancer
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摘要 目的 :比较两组不同大剂量联合化疗方案对晚期乳腺癌的疗效和毒性反应。方法 :4 7例晚期乳腺癌随机分为两组 ,A组接受大剂量表阿霉素 (HD EPI 90mg/m2 )合并常规剂量的环磷酰胺 (CTX)、5-氟脲嘧啶 ( 5 FU) ,每 2 1天重复 ;B组接受大剂量的顺铂 (HD DDP 10 0mg/m2 ) ,联合常规剂量的足乙叶甙 (Vp 16)、EPI ,每 2 8天重复。所有患者共接受化疗 168周期 ,中位周期数 3.5周期 ( 2~ 6周期 )。结果 :A、B两组有效率分别为 69.6%和 70 .8% (P >0 .1) ,初治的有效率 ( 75.0 % ,78.6% ) ,略高于复治者 ( 63.6% ,60 .0 % )。两组主要毒副反应为骨髓抑制 ,以白细胞减少为主 ,Ⅲ、Ⅳ度分别为 2 6.1%、2 9 2 %和 13.0 %、12 .5% ;胃肠道毒性为轻、中度 ,未见明显的心、肝、肾毒性。结论 :HD EPI +CTX +5 FU及HD DDP +Vp 16+EPI方案治疗晚期乳腺癌安全 ,有很好的疗效 ,可作为难治性晚期乳腺癌的一线方案。 Objective:To compare the efficacy and safety of two different high dose chemoterapy protocols for advanced breast cancer.Methods: 47 patients with advanced breast cancer (stageⅢ-Ⅳ) were randomized into two groups: 23 patients were treated with epirubicin 90 mg/m 2,cyclophosphamide 600 mg/m 2 d 1;5 FU 900 mg/m 2 d 1,8 ,every 21 days (A group).The other 24 patients were treated with cisplatin 50 mg/m 2 d 2,8 ,epirubicin 40 mg/m 2 d 1,etopostide 70 mg/m 2 d 4~6 ,every 28 days (B group).A total of 168 cycles were administered with a median of 3,5 cycles per patient (range 2-6).Results:The response rate was 69.6% in the A group and 70.8% in the B group,respectively.The difference between the two groups was not statistically significant ( P >0.1) The therapeutic effect was slightly better in patients initially diagnosed than in patinents with recurrence (RR: 75.0%,78.6% vs 63.6%,60.0%).The major side effect was leukopenia.Mild to moderate GI tract side effects were observed.There was no significant cardiotoxicity.Conclusions:High dose EPI combined with CTX,5 FU and high dose DDP combined with Vp 16,EPI are safe and effective regimens for patients with advanced breast cancer,They could be considered as a first line treatment regiemen for refractory breast cancer.
作者 胡平 陈萍
出处 《肿瘤防治杂志》 2000年第5期483-475,共1页 China Journal of Cancer Prevention and Treatment
关键词 乳腺肿瘤 表阿霉素 顺铂 联合化疗 治疗 breast cancer epirubicin cisplatin combination regiemen
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