血管紧张素转换酶2与糖尿病肾病

r Relationship between angiotensin-converting enzyme 2 and diabetic nephropathy

血管紧张素转换酶2（ACE2）通过将血管紧张素Ⅱ（AngⅡ）降解为Ang-（1—7），具有舒张血管、抑制平滑肌细胞增生、抗纤维化等效应，与多种疾病密切相关。在糖尿病肾病（DN）中，ACE2可通过影响组织微循环进而对糖代谢以及肾组织病变产生作用，也可通过改变机体氧化应激水平、影响。肾小管上皮．间充质转分化等参与DN的病变过程。近年来，ACE2已逐渐成为一个疾病的标志物和药物治疗的新靶点，ACE2不仅影响DN的发生、发展，也为其诊断和治疗提供了新的方法和策略。

Angiotensin- converting enzyme 2 （ACE2） plays an important role in vasodilation, antiproliferation and anti-fibrosis through enhancing the degradation of Angiotensin U to Ang- （ 1-7 ）, which is closely related with many diseases.In diabetic nephropathy, it is associated with glucose metabolism and renal lesions through regulating microcireulation.h can also change the level of oxidative stress and induce the epithelial-mesenchymal of kidney,thus participate in the development of diabetic nephropathy. And it gradually becomes a new biomarker of some diseases and a new target of medicine therapy.Recent studies indicate that ACE2 not only influences the development of diabetic nephropathy, also offers some new diagnostic and therapeutic strategies.