甲状腺功能亢进症患者血浆Ghrelin水平的变化及其影响因素

Changes of plasma ghrelin levels in patients with hyperthyroidism and relative affecting fac- tors

目的:探讨甲状腺功能亢进症(甲亢)患者血浆生长激素释放肽(Ghrelin)水平的变化及其影响因素。方法:分别于治疗前后对43例甲亢患者(观察组)与43例健康人进行甲状腺激素、空腹血糖、血浆Ghrelin、身体成分检测,并进行对比分析,探讨甲亢患者血浆Ghrelin水平的变化及影响因素。结果:观察组与对照组年龄、身高比较,差异无统计学意义(P>0.05);观察组治疗前体重、体质量指数(BMI)、体脂比例、血浆Ghrelin及超敏促甲状腺素(S-TSH)均低于对照组,而血清游离T3(FT3)、游离T4(FT4)、及空腹血糖(FPG)则高于对照组,差异具有统计学意义(P<0.01或P<0.05);观察组治疗后体重、体脂比例、BMI、Ghrelin以及S-TSH均增高,FT3、FT4及FPG降低,差异具有统计学意义(P<0.01或P<0.05);血浆Ghrelin水平与体脂比例、S-TSH均呈显著正相关(r=0.26,P<0.05;r=0.29,P<0.01),与FT3、FT4均呈显著负相关(r=-0.42,r=-0.38,P<0.01)。结论:甲亢患者血浆Ghrelin水平随甲亢病情变化而变化,与体脂比例、S-TSH呈正相关,与FT3、FT4呈负相关,对甲亢病情的评估及疗效的判定等均具有重要意义。

Objective= To discuss the changes of plasma ghrelin levels and the influencing factors in patients with hyperthyroidism. Methods= Plasma ghrelin, thyroid hormone, fasting glucose level, and body composition were detected before and after the treatment in 43 patients with hyperthyroidism （the observation group） and 43 cases of healthy people （the control group）, and then they were compared and analyzed. Results= There was no significantly difference in age, height between the observation group and the control group（P0.05）; but weight, BMI, body fat percentage, plasma Ghrelin and S-TSH in the