原发性高血压患者血清Mb和β_2-MG测定及其临床意义

Significance of detection serum myoglobin、β_2 microglobulin for essential hypertension

目的 :探讨原发性高血压病 (EH)患者血清肌红蛋白 (Mb)和 β2 -微球蛋白 (β2 - MG)的变化及其临床意义。方法 :采用放射免疫法测定 6 0例 EH患者和 30例非 EH患者的血清 Mb和 β2 - MG,并进行对照分析。结果 :EH组血清 Mb (7.6 6± 0 .5 6 mm ol/ L )和β2 - MG (2 .82± 0 .2 1mgl/ L )水平显著高于对照组的 (4 .5 7± 0 .35 mmol/ L ,2 .0 4± 0 .19m gl/ L) (P<0 .0 1,P<0 .0 5 ) ,且两者呈显著正相关 (P<0 .0 1)。血清 Mb和 β2 - MG水平 :高血压病 、 、 级组间依次递增 ,显著差异 (P均 <0 .0 5 ) ;伴有并发症者的也显著高于无并发症者的 (P均 <0 .0 5 )。结论 :Mb、β2 -

Objective:To explore the significance of detection serum myoglobin(Mb) and β 2 microglobulin(β 2 MG) for essential hypertension(EH).Methods:Determination serum Mb and β 2 MG were performed in 60 patients with EH and 30 cases of no EH objects by radioimmunoassay.Results:Levels of serum Mb(7 66±0 56mmol/L) and β 2 MG(2 82±0 21mgl/L) were increased significantly( P <0 01, P <0 05) in EH patients compared with control group(4 57±0 35mmol/L,2 04±0 19mgl/L).Levels of serum Mb and β 2 MG of EH Ⅰ、Ⅱ、Ⅲ stage were increased progressively by turn( P <0 05 all);Levels of serum Mb and β 2 MG of EH patients with complication were higher than no complication group( P <0 05 all).Conclusion:Detection serum Mb and β 2 MG are useful for evaluating patient's condition and impaired target organ of essential hypertension. Author′s address Lishui Hospital,Lishui,Zhejiang,323000