摘要
采用荧光偏振免疫法对190例眼用丙戊酸的癫痫患者进行丙戊酸血浓度监测,分析总结了417份血药浓度与剂量及疗效的关系,达到丙戊酸治疗血浓度范围(50~100μg/ml)但未有效控制症状的有34例次,占15%;不在治疗血药浓度范围内而症状控制良好的有43例,占21%。结果表明,丙戊酸血浓度监测对抗癫痫药物合理应用有重要指导作用,但个体化给药还必须综合考虑各方面的因素。
The serum concentrations of valproic acid in 190 epileptic patients were determined by using flu- orescence polarization immunoassay. The relations between the serum concentration of valproic acid and the dosage and therapeutic effects in 417 samples were studied. Thirty-four patients with effective serum concentra- tions of valproic acid did not have their epilepsy controlled, accounting for 15 %, while 43 patients whose serum concentrations of valproic acid were below effective level had their epilepsy controlled, accounting for 21%. It was suggested that serum concentration monitoring for valproic acid might play a key role in guiding rational use of antiepileptic drugs and various factors should be considered while practicing the individualized administration of drug.
出处
《同济医科大学学报》
CSCD
2000年第6期600-601,共2页
Acta Universitatis Medicinae Tongji
关键词
丙戊酸
血药浓度监测
个体化给药
癫痫
抗癫痫药
valproic acid
therapeutic drug monitoring
drug administration with individuation