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190例癫痫患者丙戊酸血浓度监测及个体化给药 被引量:3

Monitoring of the Serum Concentration of Valproic Acid and Drug Administration with Individuation in 190 Epileptic Patients
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摘要 采用荧光偏振免疫法对190例眼用丙戊酸的癫痫患者进行丙戊酸血浓度监测,分析总结了417份血药浓度与剂量及疗效的关系,达到丙戊酸治疗血浓度范围(50~100μg/ml)但未有效控制症状的有34例次,占15%;不在治疗血药浓度范围内而症状控制良好的有43例,占21%。结果表明,丙戊酸血浓度监测对抗癫痫药物合理应用有重要指导作用,但个体化给药还必须综合考虑各方面的因素。 The serum concentrations of valproic acid in 190 epileptic patients were determined by using flu- orescence polarization immunoassay. The relations between the serum concentration of valproic acid and the dosage and therapeutic effects in 417 samples were studied. Thirty-four patients with effective serum concentra- tions of valproic acid did not have their epilepsy controlled, accounting for 15 %, while 43 patients whose serum concentrations of valproic acid were below effective level had their epilepsy controlled, accounting for 21%. It was suggested that serum concentration monitoring for valproic acid might play a key role in guiding rational use of antiepileptic drugs and various factors should be considered while practicing the individualized administration of drug.
出处 《同济医科大学学报》 CSCD 2000年第6期600-601,共2页 Acta Universitatis Medicinae Tongji
关键词 丙戊酸 血药浓度监测 个体化给药 癫痫 抗癫痫药 valproic acid therapeutic drug monitoring drug administration with individuation
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参考文献5

  • 1陈新谦 金有豫.新编药物学(第14版)[M].北京:人民卫生出版社,1997.487.
  • 2李家泰.临床药理学(第2版)[M].北京:人民卫生出版社,1997.661-663.
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  • 4陈新谦,新编药物学(第14版),1997年,203页
  • 5陈刚,治疗药物监测.理论与实践,1988年,397页

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