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贝伐珠单抗在局部进展期直肠癌新辅助治疗中的应用进展 被引量：2

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摘要 直肠癌发病率居消化道恶性肿瘤的第2位,随着社会经济的不断发展,人们饮食结构及饮食习惯的改变,以及周围环境的影响,其发病率在逐年上升,每年新增患者超过40 000例[1].中低位直肠癌所占比例较高,就诊时多数肿瘤处于局部进展期,严重威胁着患者的健康.随着全直肠系膜切除术（total mesorectal excision,TME）及以氟尿嘧啶为基础的新辅助放化疗的提出和发展应用,提高了根治性手术切除率、保肛率,并降低了肿瘤局部复发率[2 - 3].但以氟尿嘧啶为基础的新辅助放化疗的完全病理缓解率及降期率仍较低,肿瘤术后远处转移率及5年生存率提高并不明显.…… 作者简介：江时建（1985-）,男,安徽安庆人,硕士研究生,主要进行结直肠肿瘤的靶向治疗的研究;E-mail：353078386@qq.com.
作者 江时建 朱代华
机构地区 重庆医科大学附属第二医院胃肠肛肠外科
出处 《现代医药卫生》 2014年第4期535-538,共4页 Journal of Modern Medicine & Health
关键词 直肠肿瘤 治疗 化学疗法 辅助 抗体 单克隆 综述 贝伐珠单抗
分类号 R735.37 [医药卫生—肿瘤]
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参考文献27

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二级参考文献9

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现代医药卫生
2014年 第4期

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