摘要
目的 评价盐酸氨溴索静脉给药应用于有创机械通气患者的效果.方法 检索Cochrane Library、PubMed、Elsevier (ScienceDirect)、OVID系列医学数据库、中国学术期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、万方数据库,搜集关于盐酸氨溴索静脉给药治疗有创机械通气患者的临床随机对照实验文献.采用RevMan5.0软件对检索到的文献进行Meta分析.结果 14篇文献纳入研究,共计1 184例机械通气患者.Meta分析结果表明:观察组血气分析、动脉二氧化碳分压指标水平均优于对照组,差异有统计学意义.观察组气道阻力及压力、气道峰压、平均气道压、内源性呼气末正压均低于对照组,差异有统计学意义.观察组肺顺应性、动态顺应性均优于对照组,差异有统计学意义.祛痰效果、呼吸机相关性肺炎发生率和pH,2组间比较差异无统计学意义.结论 氨溴索静脉用药可以改善有创机械通气患者呼吸力学状态,需要大样本多中心高质量的随机对照试验进一步证实其疗效.
Objective To evaluate the therapeutic effect of intravenously use of ambroxol in treatment of mechanical ventilator patients.Methods Meta-analysis was used.The Cochrane Library,PubMed,Elsevier (ScienceDirect),OVID series medical databases and domestic main databases were searched,the quality of included studies was evaluated by certain standards.The Review Manager 5.0 software was used for analysis.Results 14 studies were included,1 184 mechanical ventilation patients were involved.The Meta-analysis showed that there were significant differences between two groups in blood gas analysis,airway resistance and pressure and lung compliance.However,there were no differences between two groups in expectorant effect and VAP incidence.Conclusions Intravenously use of ambroxol in treatment of mechanical ventilator patients was effective.A large multi-center sample of high-quality clinical studies is needed to confirm the results.
出处
《中国实用护理杂志》
北大核心
2014年第4期15-21,共7页
Chinese Journal of Practical Nursing
关键词
氨溴索
机械通气
META分析
Ambroxol
Mechanical ventilation
Meta-analysis