羟基喜树碱、顺铂、亚叶酸及5-氟脲嘧啶联合治疗Ⅳ期胃肠道癌54例临床报告

Clinical Effect of HCPT+DDP+CF and 5-Fu on the Treatment of 54 Cases of PhaseⅣ Gastrointestinal Cancer

目的 观察羟基喜树碱 (HCPT)、顺铂 (DDP)、亚叶酸 (CF)及 5 -氟脲嘧啶 ( 5 -FU)联合治疗Ⅳ期肠道癌的疗效与毒副反应。方法 5 4例Ⅳ期胃肠道癌均应用HCPT +DDP +CF +5 -Fu方案全身化疗 2周期以上。结果 5 4例中CR 3例 ,PR 2 2例 ,总有效率5 1 8%。毒副反应主要是胃肠道反应 ,骨髓抑制 ,一过性肾功损伤及脱发。结论 HCPT +DDP +CF +5 -FU是治疗Ⅳ期胃肠道癌的有效方案 ,其毒副反应病人可耐受。

Objective To observe the clinical effect and side reactions of HCPT+DDP+CF and 5-Fu on the treatment of phase Ⅳ gastrointestinal cancer.Methods 54 cases of phase Ⅳ gastrointestinal cancer were treated with the regimen of HCPT+DDP+CF and 5-Fu for more than two cycles.Results Three of 54 cases got the complete response and twenty two part response.The total response rate was 51.8%.The major side reactions were gastrointestional tract reaction,myelosuppression,temporary kidney functional damage and alopecia.Conclusion The regimen of HCPT+DDP+CF and 5-Fu is effective in the treatment of phase Ⅳ gastrointestinal cancer,and well tolerated.