摘要
为观察中药方剂血府逐瘀汤对冠心病血瘀模型家兔血液流变学的影响,将32只健康家兔随机分为对照组、模型组、假手术组、中药组4组,每组8只。模型组采用左冠状动脉放置缩窄环方法,制备冠心病血瘀模型;假手术组开胸但不放置缩窄环;中药组在模型组基础上按20g/kg每天1次灌服血府逐瘀汤,连续10d。对照组、模型组、假手术组则给予等体积生理盐水,观察血液流变学的变化。结果显示,与对照组比较,模型组全血比黏度、全血还原比黏度、红细胞压积均显著升高,差异极显著(P<0.01),血栓的形成时间显著降低,差异极显著(P<0.01),体外血栓形成质量、血小板凝聚率、红细胞滤过指数均升高,差异显著(P<0.05)或极显著(P<0.01)。与模型组比较,中药组全血比黏度、全血还原比黏度、红细胞压积均显著降低,差异极显著(P<0.01),同时,中药组体内血栓的形成时间显著升高,差异极显著(P<0.01),体外血栓形成质量、血小板凝聚率、红细胞滤过指数均降低,差异极显著(P<0.01)或显著(P<0.05)。表明血府逐瘀汤能改善血瘀模型家兔血液流变学异常状况,使血液恢复正常的流动性,但具体的分子机制仍有待进一步研究。
To observe the effects of Xuefu Zhuyu decoction on hemorheology in the rabbits with coronary heart disease at the stage of blood stasis syndrome,thirty-two healthy rabbits were randomly divided into control group,model group,sham-operation group and traditional Chinese medicine group (TCM)with eight rabbits in each group.The constrictor rings were implanted in left coronary artery to establish the model of coronary heart disease at the stage of blood stasis syndrome.The rabbits in sham-operation group j ust were opened the chest but not implanted the constrictor ring.On the basis of the model group,the rab-bits in TCM group were intragastrically administrated Xuefu Zhuyu decoction according to 20 g/kg,once a day for continuous ten days while the rabbits in the control group,the model group and the sham-operation group were given the same volume of normal saline,then to observe the changes of hemorheology.The re-sults showed that as compared with the control group,in the model group,the viscosity of whole blood,re-vivification viscosity of whole blood and hematocrit(HCT)all increased and the difference was very signifi-cant (P〈0.01),the thrombogenesis time reduced and the difference was very significant(P〈0.01),the quality of thrombogenesis,cohesion rate of blood platelet,red blood cell index of filtration (IF)all in-creased,and the difference was very significant or significant(P〈0.01 or P〈0.05).When compared with the model group,in TCM group,the viscosity of whole blood,revivification viscosity of whole blood and HCT all reduced,and the difference was very significant (P〈0.01),the thrombogenesis time increased, and the difference was very significant(P〈0.01),while quality of thrombogenesis,cohesion rate of blood platelet and red blood cell index of filtration(IF)all reduced,and the difference was very significant or sig-nificant(P〈0.01 or P〈0.05).It was supposed that Xuefu Zhuyu decoction improved the pathologic chan-ges of hemorheology in rabbits with coronary heart disease at the stage of blood stasis syndrome,and re-stored the normal mobility of blood.However,further researches were needed to explain its therapeutic mechanism.
出处
《动物医学进展》
CSCD
北大核心
2014年第3期44-47,共4页
Progress In Veterinary Medicine
基金
广西科学研究与技术开发计划项目(桂科攻1347003-4)
关键词
血府逐瘀汤
血瘀证
冠心病
血液流变学
家兔
Xuefu Zhuyu decoction
blood stasis syndrome
coronary heart disease
hemorheology
rabbit