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雷贝拉唑四联疗法与枸橼酸铋雷尼替丁三联疗法治疗幽门螺杆菌相关性消化性溃疡效果对比研究 被引量:41

A Comparative Study of Rabeprazole Quadruple Therapy and Ranitidine Bismuth Citrate Cap Triple Therapy in Treatment of Helicobacter Pylori Associated Peptic Ulcer
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摘要 目的对比评价雷贝拉唑四联疗法与枸橼酸铋雷尼替丁(RBC)三联疗法治疗幽门螺杆菌(Hp)相关性消化性溃疡的临床效果。方法选择2011年5月—2012年5月在中山市火炬开发区医院治疗的Hp相关性消化性溃疡78例,以随机数字法分为雷贝拉唑四联疗法组(四联组)和RBC三联疗法组(三联组),每组39例。四联组予雷贝拉唑胶囊+克拉霉素+左氧氟沙星+枸橼酸铋钾治疗,7 d后单服雷贝拉唑,连用3周,疗程4周;三联组予RBC+克拉霉素+左氧氟沙星治疗,7 d后单服RBC,连用3周,疗程4周。比较两组治疗后临床症状缓解率、Hp根除率、溃疡愈合率及不良反应发生率。结果两组治疗1、4周后,临床症状缓解率差异无统计学意义(χ2=0.003,P=0.956;χ2=4.088,P=0.056);治疗4周后两组Hp根除率、溃疡愈合率、不良反应发生率比较差异均无统计学意义(χ2=0.244,P=0.674;χ2=2.078,P=0.176;χ2=0.254,P=0.615)。结论雷贝拉唑四联疗法和RBC三联疗法治疗Hp相关性消化性溃疡安全、高效,均可作为治疗Hp相关性消化性溃疡的一线方案。 Objective To compare the clinical effect of Rabeprazole quadruple therapy and Ranitidine Bismuth Citrate Cap (RBC) triple therapy in treatment of helicobacter pylori (Hp) associated ulcer. Methods A total of 78 pa- tients with Hp associated ulcer during May 2011 and May 2012 in our hospital were divided into Rabeprazole quadruple therapy group ( group A, n = 39) and RBC triple therapy group ( group B, n = 39) according to random number method. Group A was treated with Rabeprazole capsules + Clarithromycin + Levofloxacin + Bismuth Potassium Citrate for 7 d, and then changed for Rabeprazole for 3 weeks, and the course of treatment was 4 weeks; group B was treated with RBC + Clarithromycin + Levofloxacin for 7 d, and then changed for RBC for 3 weeks, and the one course of treatment was 4 weeks. The relief rate of clinical symptoms, Hp eradication rate, the healing rate of ulcer and incidence rate of ad- verse reactions in the two groups after treatment were compared. Results There was no significant difference in relief rate of clinical symptoms in the two groups after treatment for one week and four weeks (x^2 = 0. 003, P = 0. 956 ;x^2 = 4. 088, P = 0. 056) ; there were no significant differences in Hp eradication rate, healing rate of ulcer and incidence rate of adverse reactions in the two groups after treatment for four weeks (x^2 = 0. 244, P = 0. 674 ; x^2 = 2. 078, P = 0. 176 ;x^2= 0. 254, P = 0. 615). Conclusion Rabeprazole quadruple therapy and RBC triple therapy in treatment of Hp asso- ciated peptic ulcer are safe and effective, and both can be used as the preferred drugs.
作者 吴文海
出处 《解放军医药杂志》 CAS 2014年第2期69-71,74,共4页 Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词 雷贝拉唑 枸橼酸铋雷尼替丁 螺杆菌 幽门 消化性溃疡 Rabeprazole Ranitidine bismuth citrate cap Helicobacter, pylorus Peptic ulcer
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