2型糖尿病合并高血压患者血清脂联素与臂-踝脉搏波传导速度的关系

Relationship of adiponectin and brachial ankle pulse wave velocity in type 2 diabetes mellitus patients combined with hypertension

目的 探讨2型糖尿病合并高血压患者脂联素与臂-踝脉搏波传导速度（baPWV）的关系.方法 选择2010年3月至2012年3月来我院就诊的糖尿病患者56例,糖尿病合并高血压患者69例,另选择同期健康体检者78名分别进行脂联素和baPWV检测,分析各组间脂联素和baPWV的相关性.结果 糖尿病合并高血压组患者脂联素为（7.6±2.4） mg/L,糖尿病组为（9.1±3.8）mg/L,健康对照组为（13.9±4.2） mg/L,3组间两两比较差异均有统计学意义（F=62.53,P＜0.01）.糖尿病合并高血压组、糖尿病组和健康对照组baPWV分别为（2 196.1 ±218.6）、（2 010.9±231.7）、（1 617.4±198.2） cm/s,3组间两两比较差异均有统计学意义（F=139.41,P＜0.01）;糖尿病合并高血压组、糖尿病组和健康对照组脂联素水平和baPWV之间均有较好的相关性（r值分别为-0.629、-0.561、-0.528,P值分别为0.027、0.034、0.029）.结论 糖尿病合并高血压患者血清脂联素下降,同时baPWV升高,且二者之间有较好的相关性.

Objective To explore the relationship of adiponectin and brachial ankle pulse wave velocity （baPWV） in type 2 diabetes mellitus patients combined with hypertension.Methods Fifty-six patients with diabetes mellitus,69 diabetes mellitus patients combined with hypertension and 78 healthy people were recruited in our study who visited doctors in Fenyang Hospital from March 2010 to March 2012.The levels of adiponectin,brachial ankle pulse wave velocity and other biochemical indicator were determined.Analyzed the correlation between adiponectin and baPWV among the three groups.Results The levels of adiponectin in control group,diabetes mellitus group,and diabetes mellitus combined with hypertension group were （13.9 ±4.2） mg/L,（9.1 ± 3.8） mg/L and （7.6 ± 2.4） mg/L respectively,and the difference was statistically significant （F =62.53,P ＜0.01）.The levels of baPWV in control group,diabetes mellitus group and diabetes mellitus combined with hypertension group were （1 617.4 ± 198.2） cm/s,（2 010.9 ±231.7） cm/s and （2 196.1 ±218.6） cm/s respectively,and the difference was also statistically significant （F =139.41,P ＜ 0.01）.The correlation between adiponectin level and baPWV among three groups were-0.629,-0.561,and-0.528,respectively （P =0.027,0.034,0.029）.Conclusion The levels of adiponectin decreased in diabetes mellitus patients combined with hypertension,while the baPWV increased.There is a good correlation between adiponectin and baPWV.