摘要
目的观察缬沙坦联合阿托伐他汀钙对早期糖尿病肾病患者的治疗作用。方法将确诊为早期糖尿病肾病的62例患者随机分为缬沙坦组、联合治疗组。联合治疗组应用缬沙坦和阿托伐他汀钙治疗;缬沙坦组用缬沙坦治疗,均连续治疗12周,比较两组治疗前后及两组治疗后尿微量白蛋白量、胱抑素、C-反应蛋白、血清总胆固醇、低密度脂蛋白胆固醇等指标的变化。结果将两组治疗前后及联合治疗组与缬沙坦组治疗后分别比较显示,差异有统计学意义(P<0.05)。结论缬沙坦联合阿托伐他汀钙在治疗糖尿病早期阶段能减少患者尿微量白蛋白排泄量,减轻炎症反应,改善肾功能,两药合用起到了协同作用。
Objective To observe the effects of valsartan combined with atorvastatin in the treatment of early diabetic nephropathy. Methods Sixty-two cases were divided into two groups randomly, the control group were treated with valsartan while, the study group were treated with valsartan combined with atorvastatin; after treating for 12 weeks, the clinical effect of the two groups were observed. Results The two groups before and after treatment, the combined treatment group after treatment compared with the valsartan group, the difference was statistically significant （P 〈 0.05）. Conclusion Valsartan joint atorvastatin in the treatment of early diabetic nephropathy can reduce the urine trace albu- min excretion and reduce inflammation, improve renal function, curative effect affirmation, two appears to play a synergy.
出处
《中国现代医生》
2014年第8期62-64,共3页
China Modern Doctor
