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利塞膦酸钠治疗绝经后老年女性骨质疏松症临床研究 被引量：7

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摘要 目的观察利塞膦酸钠对绝经后老年女性骨质疏松的影响。方法患者64例,试验组和对照组按1∶1比例分配,每组32例。试验组以利塞膦酸钠加钙尔奇D600治疗,对照组以钙尔奇D600治疗,治疗6个月,在治疗前、用药后6个月末及用药期间随访,对利塞膦酸钠的有效性及安全性进行评估。结果治疗6个月后,两组患者临床症状均有不同程度改善,试验组和对照组的总有效率分别为90.625%和59.375%;两组患者的腰椎BMD、全髋部BMD等均好转,与治疗前相比具有显著性差异(P<0.05),且试验组改善程度优于对照组(P<0.05);治疗期间,没有发生严重不良事件。结论利塞膦酸钠能有效治疗绝经后妇女骨质疏松症,且不良反应小。
作者 陈小青 陈明珠 曾荣东
机构地区 福建省泉州市第一医院骨科 泉州医学高等专科学校药学系
出处 《海峡药学》 2014年第2期97-99,共3页 Strait Pharmaceutical Journal
关键词 骨质疏松症 利塞膦酸钠 绝经
分类号 R969.4 [医药卫生—药理学]
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参考文献2

二级参考文献31

  • 1张众志,陈璐璐,李裕明.二膦酸盐细胞分子作用机制的研究进展[J].中国骨质疏松杂志,2004,10(3):390-392. 被引量：15
  • 2Irina M, LiLian IP, Cecilia LS, et al. Extrncellar sigoal-kinase and calcium channels are involved in the proliferative effect of bisphosphonates on osteoblastic cells in vitro. J Bone Miner Res, 2001,16: 2050-2056.
  • 3Luckman SP, Hughs DE, Coxon FP, et al. Netrogen-containing bisphosphonates inhabit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including ras. J Bone Miner Res,1998, 13: 1668-1678.
  • 4Fisher JE, Rogers MJ, Hslasy JM, et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption and kinase activation in vitro. Proc Natl Acad ,Sci USA, 1999
  • 5Dunford JE, Thompson K, Coxon FP, et al. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitroge-containing bisphosphonates. J Pharmacol Exp Ther, 2001, 296: 235-242.
  • 6Frith JC, Monkkonen J, Auriola S, et al. The molecular mechanism of action of the anteresorptive and antiinflammatory drug clodronate: evidence for the formation, in vivo of a metabolite that inhabits bone resorption and causes osteoclast and macrophage a
  • 7Green JR, Clezardifl P. Mechanisms of bisphosphonates effects on osteoclasts, tumor cell growth, and metastasis. Am J Clin Oncol, 2002, 25:S3-9.
  • 8Giuliani N, Pedrazzoni M, Passeri G, et al. Bisphosphonates inhibit IL6 production by human ostcoblast-liks cells. Scand J Rheumatol, 1998,27: 38-41.
  • 9Viereck V, Emons G, Lauck V, et al. Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. Biochem Biophys Res Commun, 2002, 291:680-686.
  • 10Mackie PS, Fisher JL, Zhou H, et al. Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line. Br J Cancer, 2001, 84:951-958.

共引文献19

同被引文献81

  • 1王艳丽,谭丽.围绝经期女性骨质疏松的临床研究[J].中国实用医药,2007,2(20):26-27. 被引量：15
  • 2刘宇,莫胜丹,李瑛.中药治疗绝经后骨质疏松症的系统评价[J].海南医学,2005,16(2):136-137. 被引量：9
  • 3Li N, Ou P, Zhu H, et al. Prevalence rate of osteoporosis in the mid- aged and elderly in selected parts of China [ J 3- Chin Med J, 2002, 115 (5) : 773-775.
  • 4Nakamura I, Duong le T, Rodan SB, et al. Involvement of alpha (v) beta3 integrins in osteoclast function [ J 1. J Bone Miner Metab, 2007, 25 (6): 337-344.
  • 5Brenner DE, Kukull WA, Sterachis A, et al. Postmenopausal estrogen replacement therapy and the risk of Alzheimers disease: a population - based casecontrol study [ J :. Am J Epidemiol, 1994, 140 (3): 262-267.
  • 6颜雯,白晓苏,李涛,等.阿仑麟酸钠对绝经后女性骨质疏松症患者躁臂指数及颈动脉内膜厚度的影响[J].中华医学会第七次全国骨质疏松和骨矿盐疾病学术会议,2013.
  • 7Carbone LD, Tylavsky FA, Cauley JA,et al. Association betw- een bone mineral density and the use of nonsteroidal anti-in- flammatory drugs andaspirin: impact of cyclooxygenase selectivity[ J). J Bone Miner Res,2003 ,18(10) :1795-1802.
  • 8Kolios L, Schumann J, Schmisch S, et al. Effects of blcak cohosh (Cimicifuga racemosa) and estrogen on metaphyseal fracture healing in the early stage of osteoporosis in ovariectomized rats [ J 1- Planta Med,2010,76 (9) : 850-857.
  • 9Nappi RE, Malavasi B, Brundu B ,et al. Efficacy of Cimicifu- ga racemosaon climacteric complaints: a randomized study versus low- dose transdermal estradiol [ J 3. Gynecol Endocrinol,2005,20( 1 ) :30-35.
  • 10Palacios S, de Villiers TJ, Nardone Fde C, et al. Assessment of the safety of long- term bazedoxifene treatment on the reproductive tract in postmenopausal women with osteoporosis: results of a 7-year, randomized, placebo-controlled, phase 3 study[J].Maturitas, 2013, 76 (1): 81-87.

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二级引证文献40

海峡药学
2014年 第2期

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