蛋白磷酸酶2A的癌性抑制因子在前列腺癌中的表达及意义

Expression and clinical significance of CIP2A in prostate cancer

目的 探讨蛋白磷酸酶2A的癌性抑制因子（CIP2A）在前列腺癌中的表达及意义.方法 选取昆明医科大学第三附属医院2009年1月～2012年4月手术治疗的前列腺癌患者65例为试验组,选取同期昆明医科大学第三附属医院收治的良性前列腺增生患者65例组织标本为对照组,采用免疫印迹（Western blot）的方法对两组CIP2A的表达情况进行比较,并分析CIP2A的表达与临床病理因素的关系.结果 CIP2A在试验组中的阳性表达率为64.62％（42/65）,在对照组中阳性表达率为29.23％（19/65）,两组进行比较,差异有统计学意义（P＜0.05）;所有患者随访1年,CIP2A的阳性表达与术后1年肿瘤转移复发、分化程度、临床分期、术前血清中PSA水平有关（P＜0.05）.结论 CIP2A有望成为前列腺癌早期诊断、预测复发转移及预后评价的一个重要的生物学指标.

Objective To explore the expression and clinical significance of CIP2A in prostate cancer.Methods 65cases of prostate cancer patients from January 2009 to April 2012 in the Third Affiliated Hospital of Kunming Medical University were selected as experiment group; 65 patients with benign prostatic hyperplasia tissue in the same term in the Third Affiliated Hospital of Kunming Medical University were selected as control group,the CIP2A expression of two groups was compaed by Western blot method,the relationship of the CIP2A expression and clinical pathological factors were analyzed.Results CIP2A positive expression rate in experiment group was 64.62％ （42/65）,the positive expression rate in control group was 29.23％ （19/65）,the difference was statistically significant （P ＜ 0.05）.All the patients were followed up for 1 year,the relationship between the expression of CIP2A and the degree of differentiation,clinical stage,preoperative serum PSA levels were found,the differences were statistically significant （P ＜ 0.05）.Conclusion CIP2A is expected to become an important biological indicator of the early diagnosis of prostate cancer,recurrence,metastasis and prognosis evaluation.