中药配方颗粒剂用于高脂血症临床观察

Clinical Effect of Traditional Chinese Medicine Formula Granules on Hyperlipidemia

目的:分析观察对高脂血症采用中药配方颗粒剂临床治疗的效果。方法:选取浙江省安吉县中医医院内科2012年1月—2012年12月收治的58例高脂血症患者为研究对象,按照治疗方法不同分为常规组与血脂控制组(每组各29例)。常规组照常应用西药辛伐他汀(10 mg/次,晚间顿服)治疗,血脂控制组采用中药配方颗粒剂(山楂、水蛭、丹参)治疗,两组均接受为期1个月时间治疗,对比两组治疗前后临床治疗效果、血脂水平TC、TG、LDL-C。结果:常规组显效14例、有效10例、无效5例,治疗总有效率为82.76%;血脂控制组显效16例、有效9例、无效4例,治疗总有效率为86.21%,两组间数据比较(χ2=0.3436、t=0.5578,P>0.05)。常规组与血脂控制组治疗前后TC、TG、LDL-C均有显著改善(P<0.05),血脂控制组血脂水平与常规组血脂水平比较无统计学意义(P>0.05)。结论:中药配方颗粒剂治疗高脂血症主要有途径广、靶点多、降血脂广谱、毒副作用小等优点,能够有效抑制脂类吸收,降低血脂水平。

Objective ： To analyze and observe the effect of clinical treatment on hyperlipemia by using traditional Chinese med- icine formula granules. Methods ： Fifty - eight cases of hypedipidemia patients selected from Internal Medicine Department in Zhe- jiang Hospital of Traditional Chinese Medicine admitted from January 2012 to December 2012 were treated as research objects, and they were divided into the regular group and the blood lipid control group （29 cases in each group respectively） according to different treatment methods. The patients in the regular group were treated with Simvastatin（ 10 rag/time,administered at draught at night） and western medicine ,while the patients in the blood lipid control group were treated with traditional Chinese medicine formula granules （ hawthorn,leech, salvia miltiorrhiza）. Patients in both groups were treated for 1 month, and clinical curative effect before and after treatment, blood lipid level,TC, TG and LDL - C of patients in both groups were compared. Results ： 14 ca- ses had obvious effect, 10 cases were effective and 5 cases were of no effect in the regular group, and the total effective rate was 82.76%. 16 cases had obvious efficacy,9 cases were effective and 4 cases were of no effect in the blood lipid control group, and the total effective rate was 86.21% ,and the data comparison between two groups was significant （ X2 =0. 3436 ,t =0. 5578 ,P〉0. 05 ）. The TC,TG and LDL - C of patients in the regular group and blood lipid control group before and after treatment were improved significantly （ P 〈 0. 05 ）, and the lipid level of patients in the blood lipid control had no statistical significance when it was compared to that of patients in the regular group （ P 〉 0. 05 ）. Conclusion： The traditional Chinese medicine formula granules in treating hyperlipidemia is provided with advantages, such as multiple approaches, substantial targets, extensive blood fat reduction and few side effects. This medicine can effectively inhibit lipid absorption and reduce blood fat level.