含左氧氟沙星三联方案治疗幽门螺杆菌阳性消化性溃疡效果评价

Effect Evaluation of Levofloxacin Triple Therapy Helicobacter Pylori Positive Peptic Ulcer

目的：探讨含左氧氟沙星三联方案治疗幽门螺杆菌（Hp）阳性消化性溃疡（PU）临床价值。方法：Hp阳性PU患者182例按随机数字法分观察组及对照组各91例,对照组应用铋剂0.20g、阿莫西林1.0g、克拉霉素0.5g,每日2次,奥美拉唑40mg,1次/天,口服；观察组阿莫西林1.0g,左氧氟沙星0.4g,2次/天,奥美拉唑40mg,1次/天,口服,8天以后继续应用奥美拉唑6-8周。结果：两种腹痛缓解时间及治疗效果无显著性差异（P〉0.05）；观察组药物不良反应率10.99%低于对照组的38.76%（P〈0.05）, Hp检测阴性90.11%高于对照组76.92%（P〈0.05）,复发10.99%低于对照组的25.27（P〈0.05）。结论：含左氧氟沙星的三联疗法能降低药物不良反应、提高Hp根除率,减少复发,值得临床应用。

Objective：Study levofloxacin triple therapy regimens for Helicobacter pylori （Hp） Positive Peptic Ulcer （PU） clinical value.Methods：The Hp positive PU patients 182 were randomly divided into the observation group and the control group 91 cases,the control group using bismuth agent 0.20g,amoxicillin 1.0g,clarithromycin 0.5g,2 times daily,omeprazole 40mg,1 times/day,oral;observation group of amoxicillin 1.0g,levofloxacin 0.4g,2 times/day,omeprazole 40mg,1/day,oral,8 days later to omeprazole 6-8 weeks.Results：Two group abdominal pain relief time and the therapeutic effect no significant difference （P〉0.05）;Observation group adverse drug reactions 38.76%was lower than the control group10.99%（P〈0.05）,Hp detected 90.11%higher than the control group 76.92%（P〈0.05）,recurrence 10.99% lower than the control group 25.27 （P〈0.05）.Conclusion：Triple therapy with levofloxacin can reduce the adverse drug reaction,improve the eradication rate of Hp,reduce the recurrence,it is worthy of clinical application.