脓毒症和感染性休克治疗进展

Update in the Management of Sepsis and Septic Shock

脓毒症(sepsis)常并发感染性休克(septic shock)。近年来临床研究发现,脓毒症的早期诊断和治疗与患者的预后关系密切。本文就脓毒症和感染性休克治疗进展作一综述。主要内容包括:(1)尽早并正确地处置脓毒症,可以明显地降低近期和远期病死率;(2)扩容治疗(fluid resuscitation)和早期正确的抗生素治疗对脓毒症的生存率影响最大;(3)应该在24 h内控制感染原。

Sepsis and septic shock are syndromes that often overlap in clinical maniiestatlon. Emerging evmence suggests that early recognition and early initiation of therapy for sepsis are the most impotlant components in the management of sep- sis and septic shock. The current review is to update the management of sepsis and septic shock, including early recognition and management of sepsis significantly improves short-term and long-term mortality ; early fluid resuscitation and appropriate antibiotic therapy have the most impact on survival;and infection source should be controlled within 24 hours of initiating management.