慢性牙周炎与IgA肾病的相关性研究

Correlation between Chronic Periodontitis and IgA Nephropathy

目的探讨慢性牙周炎与IgA肾病的相关性。方法选取2010年3月—2011年11月在兰州军区乌鲁木齐总医院肾病科住院的初步诊断为原发性慢性肾小球肾炎患者83例,根据是否合并慢性牙周炎分为牙周炎组(49例)和非牙周炎组(34例)。对两组患者行肾穿刺活检术,对比两组IgA肾病的患病率,分析IgA肾病与慢性牙周炎的关系及不同程度慢性牙周炎与IgA肾病病理分级间的相关性。结果牙周炎组IgA肾病患病率(53%,26例)高于非牙周炎组IgA肾病患病率(29%,10例),差异有统计学意义(χ2=4.571,P=0.032)。重度慢性牙周炎患者IgA肾病患病率较非牙周炎组和轻度牙周炎患者均高,差异有统计学意义(χ2=9.070、4.644,P=0.003、0.031)。经Spearman相关性分析显示,不同程度慢性牙周炎与IgA肾病病理分级呈正相关(r=0.5313,P<0.01)。结论慢性牙周炎与IgA肾病的发病、发展有关,且随着慢性牙周炎程度的加重IgA肾病的病情加重。

Objective To Investigate the correlation between chronic periodontitis （CP） and IgA nephropathy （IgAN）. Methods Eighty -three patients diagnosed initially as primary IgAN from March 2010 to November 2011 were divid- ed, according to combination with CP, into groups CP （ n = 49 ）, non - CP （ n = 34 ）. Renal needle biopsy was performed to confirm patients＇ IgA prevalence, and its relationship to varying degrees of CP in different groups and correlation between different degrees of CP and pathological gradings of IgAN were analyzed. Results The IgA prevalence was higher in CP group （53%） than in non - CP group （ 29% ）, the difference was significant （ X2 = 4. 571, P = 0. 032 ）. The IgA prevalence was higher in severe CP patients than non - CP and mild CP patients （ X2 = 9. 070, 4. 644 ; P = 0. 003, 0. 031 ）. By spearman correlation a- nalysis, different degrees of CP was correlated with IgAN pathological grading （ r = 0. 5313, P 〈 O. O1 ） , and the grading in- creased with the severity of CP. Conclusion CP is related to the onset and development of IgAN to some extent, and IgAN be- comes worse with the aggravation of CP.