采用连续性肾脏替代与间歇性血液透析治疗重症急性肾衰竭的临床效果对比研究

Using continuous renal replacement and intermittent hemodialysis therapy of severe acute renal failure the clinical effect of comparative study

目的回顾性地将重症急性肾功能衰竭(ARF)情况下所使用的连续性肾脏替代疗法(CRRT)与间歇性血液透析疗法(IHD)进行临床治疗效果对比。方法以自2011年1月至2012年5月接受重症急性肾功能衰竭的104例患者为对象,按照治疗方法的不同分别归入C组(43例)和I组(61例)中,其中C组患者均采用连续性肾脏替代疗法进行重症急性肾功能衰竭治疗,I组患者均采用间歇性血液透析疗法接受治疗。经治疗12个月后,观察尿素氮(BUN)、血清肌酐(Scr)、内生肌酐(Ccr)等指标以及最终存活率。结果根据各类临床资料显示,C组患者在接受治疗后BUN降至(19.32±4.54)mmol/L,Scr降至(410.37±138.41)μmol/L,Ccr升至(23.78±10.96)μmol/L,P<0.05;I组患者BUN降至(26.03±3.59)mmol/L,Scr降至(423.41±152.84)μmol/L,Ccr升至(14.82±8.36)μmol/L,P<0.05;随访调查对象存活率为C组88.4%、I组51.6%。结论治疗重症急性型肾功能衰竭,CRRT不仅效果好,且存活率高,临床效果明显优于IHD。

Objective Retrospectively will severe acute renal failure （ARF） cases the use of continuous renal replacement ＂therapy （CRRT） and intermittent hemodialysis therapy （IHD） for clinical treatment effect comparison. Methods To since January 2011 - May 2012 accept severe acute renal failure of 104 patients for object, according to the different treatment methods were classified as group C （43 cases） and I group （61 cases）, including C groups were all use continuous renal replacement therapy in severe acute renal failure treatment, and patients I all use intermittent hemodialysis therapy treatment. After a period of time after treatment, will C group and I set of all kinds of clinical data, two years later observation eventually survival rate. Results According to various clinical data showed that patients in group C after treatment urea nitrogen （BUN） , down from （19.32± 4.54）mmol/L, serum creatinine （Scr） dropped to （410.37 ±138.41 ）μmol/L, endogenous creatinine （Ccr） to （23.78±10.96） μmol/L, P 〈0.05 ; I patients BUN dropped to （26.03 ±3.59） mmol/L, Scr dropped to （423.41 ± 152.84）μmoL/L, Ccr to （14.82＋8.36） μmol/L,P〈0.05;AftervisitingsurveyforsurvivalCRRT88.4%,IHD51.6%. Conclusion Treatments for severe acute renal failure, CRRT not only effect is good, and the survival rate is high, the clinical effect was better than IHD.