养心复脉口服液治疗早搏的临床与实验研究

Clinical and Experimental Study of Effect of Yangxin Fumai Oral Liquid in Treating Patients with Extrasystole

目的 :评价养心复脉口服液对于早搏的治疗效果。方法 :用养心复脉口服液治疗各类早搏患者 30例 ,同期设心律平对照组 30例进行观察 ,并就该方对实验性心律失常的影响进行了动物实验研究。结果 :临床观察表明治疗组的抗早搏作用与对照组相当 ,在改善患者症状方面明显优于对照组 (P <0 0 1) ,且未见明显毒副作用。实验研究显示养心复脉口服液可降低氯仿致小鼠的室颤率 ,推迟乌头碱、氯化钡、冠状动脉结扎等引起的大鼠室性早搏、室性心动过速、心室颤动的出现时间 ,或缩短心律失常的持续时间、降低室性早搏的发生率 ,与空白对照组比较差异有显著性 (P <0 0 5,P <0 0 1)。结论 :养心复脉口服液是临床治疗各类早搏疗效较好、服用方便。

Objective: To evaluate the therapeutic effect of Yangxin Fumai Oral Liquid (YFOL), a Chinese herbal medicine for nourishing heart and restoring pulse, in treating patients with extrasystole. Methods: The effect of YFOL was observed in treating 30 patients with different kinds of extrasystole and compared with that in 30 patients treated by propafenone. The effect of YFOL on experimental arrhythmia was studied in animals as well. Results: Clinical observation showed that the effect of YFOL against extrasystole in the two groups was similar, but the YFOL group showed better effect in symptom improvement (P<0 01) with no marked side effects. Experimental study showed that YFOL could reduce the chloroform induced ventricular fibrillation occurrence in mice, delay the initiating time of ventricular extrasystole, tachycardia and fibrillation induced by aconitine, BaCl 2 and coronary artery ligation in rats, or shorten the lasting time of arrhythmia, reduce the attacking rate of ventricular extrasystole. There was significant difference in comparing with the control group (P<0 05, P<0 01). Conclusion: YFOL is a good and convenient Chinese herbal preparation for different kinds of extrasystole with low toxic and side effects in clinical practice.