血清甲胎蛋白异质体3测定在原发性肝癌早期筛查中作用

Value of serum alpha-fetoprotein detection in early screening of primary liver cancer

目的探讨血清甲胎蛋白异质体3(AFP-L3)在原发性肝癌早期筛查中的作用。方法以装有耦联小扁豆凝集素(LCA)的微量离心柱分离慢性肝病、原发性肝癌共116例患者AFP-L3,用化学发光方法检测分离前后AFP-L3,计算AFP-L3在AFP中的含量比例。结果原发性肝癌组AFP-L3含量比例均值[(36.89±2.13)%],与慢性肝病组[(7.45±2.32)%]相比差异有统计学意义(P<0.01)。结论微量离心柱法测定AFP-L3的含量在原发性肝癌的早期筛查中具有重要意义。

Objective To explore the value of serum alpha-fetoprotein （ AFP-L3 ） in early screening of primary liver cancer. Methods Lentil lectin coupled with （LCA） micro-centrifuge column was separated to obtain AFP-L3 from 116 cases of chronic liver disease and primary liver cancer. AFP before separation and AFP-L3 after separation were detected with chemoluminescence, and their levels were then calculated. Results Statistical differences could be seen in the average value of AFP-L3 between the patients with pri- mary liver cancer and patients with chronic liver disease （P 〈 0.01 ）. Conclusion The level detected with micro-centrifuge column was of importance in early screening of primary liver cancer.