中药材特征性总成分指纹鉴定

Authentication of Traditional Chinese Herbal Medicines (TCHM) by Fingerprints of Characteristic General Constituents

目的 :论述中药材特征性总成分指纹鉴定的理论、科学意义、特色及其可行性。方法 :总结前期研究工作和文献工作 ,对植物类中药材鉴定的国内外研究现状进行分析。结果 :按一定的程序可获取植物类中药材具特征性的总提取物 ,用其波谱指纹特征表征其组成和结构 ,可以准确鉴定植物类中药材的品种 ;结合不同来源的同品种中药材特征总提物的含量对其品质作出评价。结论 :中药材特征性总成分指纹鉴定对植物中药的品种鉴别和品质评价具有重要意义。

Objective: To describe the theory, scientific significance, distinguishing features and authentication feasibility of TCHMs by spectral fingerprints of characteristic general constituents. Method: Previous relevant investigations and literatures were summed up in the field, and the present situation on the authentication of TCHMs at home and abroad was analysed. Result: The characteristic general constituents of TCHMs can be obtained by an appropriate procedure. Their compositions and structures can be determined by spectral fingerprints, especially the 1 HNMR fingerprint. The species of TCHMs can be identified accurately by these fingerprints. Besides, the quality of TCHMs can be evaluated by the contents of their GCEs. Conclusion: Fingerprint authentication of characteristic general constituents of TCHMs has profound significance for the species identification and quality evaluation of TCHMs. [