0.2％罗哌卡因用于患者超声引导星状神经节阻滞的量效关系

Dose-response relationship of 0.2% ropivacaine for ultrasound-guided stellate ganglion block

目的 确定0.2％罗哌卡因用于患者超声引导星状神经节阻滞（SGB）的量效关系.方法 拟行SGB的偏头痛患者75例,年龄23 ～ 55岁,体重指数22 ～ 28 kg/m2,ASA分级Ⅰ或Ⅱ级,采用随机数字表法,将其分为5组（n=15）,在超声引导下行SGB时R1组、R2组、R3组、R4组和R5组分别注射0.2％罗哌卡因1、2、3、4、5 ml.以出现同侧霍纳综合征作为SGB成功的标准.采用probit概率单位法计算50％和95％患者SGB的有效剂量（ED50和ED95）及其95％可信区间（CI）.结果 0.2％罗哌卡因用于患者超声引导SGB的ED50为2.2 ml（95％CI 1.9～ 2.5 ml）,ED95为3.2 ml（95％ CI 2.8 ～4.1ml）.结论 0.2％罗哌卡因用于患者超声引导SGB的ED50和ED95分别为2.2、3.2 ml.

Objective To determine the dose-response relationship of 0.2% ropivacaine for ultrasoundguided stellate ganglion block （SGB）.Methods Seventy-five ASA physical status [or Ⅱ patients with migraine,aged 23-55 yr,with body mass index of 22-28 kg/m2,scheduled for elective ultrasound-guided SGB,were randomly divided into R1-5 groups （n =15 each） using a random number table.In R1,R2,R3,R4 and R5 groups,the patients underwent ultrasound-guided SGB with 0.2% ropivacaine 1,2,3,4 and 5 ml,respectively.A successful SGB block was confirmed by the onset of ptosis （Horner syndrome） on the injected side.Probit analysis was used to calculate the effective dose of 0.2 % ropivacaine in 50 % and 95 % of the patients （ED50 and ED95） and 95% confidence interval （95% CI）.Results The ED50 of 0.2% ropivacaine for ultrasound-guided SGB was 2.2 ml （95%CI 1.9-2.5 ml） and ED95 was 3.2 ml （95%CI 2.8-4.1 ml）.Conclusion The ED50 and ED95 of 0.2% ropivacaine for ultrasound-guided SGB are 2.2 and 3.2 ml,respectively.