口服二甲双胍血糖控制不佳的2型糖尿病患者加用地特胰岛素的疗效观察

The curative effect of insulin detemir as add-on therapy to previous oral metformin with poor glycemic control of type 2 diabetes

目的观察口服二甲双胍(Met)血糖控制不佳的T2DM患者加用地特胰岛素(Det)治疗的有效性。方法选取口服Met血糖控制不佳的T2DM患者70例,Met联合Det治疗12周,测定患者治疗前后FPG、2hPG、HbAl c、FC-P、C-P、BMI、BP、血脂及胰岛素抵抗指数(HOMA-IR)等。结果Met联合Det治疗12周后,FPG、2hPG、TG、LDL-C、HbAl c及HOMA-IR较治疗前下降(P<0.05);FCP及C-P升高(P<0.05)。结论口服Met血糖控制不佳的T2DM患者联合Det治疗可有效控制血糖,改善胰岛β细胞功能,调节血脂,且不增加体重。

Objective To study The curative effect of insulin detemir as add-on therapy to previous oral metformin with poor glycemic control of type 2 diabetes Methods 70 type 2 diabetic patients treated with pure oral metformin with poor glycemic control were selected to receive treatment of insulin detemir for 12 weeks. Before and after above treatments, the following parameters were measured and ealculated, including FPG, 2 hPG, HbAlc, FC-P, 2 hC-P, BMI, SBP, DBP, TG, TC, LDL-C, HDL-C, HOMA-IR. Results After 12 weeks of treatment with metforrnin combined with insulin detemir, the parameters of FPG, 2 hPO, TG, LDL-C, HbAt c and HOMA-IR were decreased （P〈0.05）, and the levels of FC-P and 2 hC-P were increased （P〈 0. 05）, as compared with pre-treatments. Conclusion The combination treatment of insulin detemir and metformin for the type 2 diabetic patients, who suffered from poor glycemic control, can effectively control the blood glucose, improve the function of islet cells, and regulate the blood lipids,without increasing body weight.