急性百草枯中毒患者百草枯含量、肾及肺功能指标对其预后影响

The Effect of Paraquat Levels,Kidney and Lung Function in Patients with Acute Paraquat Poisoning to Prognosis

目的:研究急性百草枯中毒患者的百草枯含量、肾功能指标和肺功能指标与其预后关系。方法:选择107例急性百草枯中毒患者为研究对象,根据预后分为存活组和死亡组,检测患者血尿的百草枯含量、肾功能指标和肺功能指标。结果:死亡组患者的血浆百草枯含量、尿液百草枯含量分别为9.54±1.13mg/和423.23±63.43mg/L均高于存活组;血肌酐、血尿素氮、二氧化碳分压(PaCO2)分别为141.8±18.2mmol/L、11.4±2.2mmol/L和1.32±6.32mmHg,均高于存活组,氧分压(PaO2)、实际碳酸氢盐(PCO3-)和剩余碱(BE)分别为79.44±10.42mmHg、14.82±2.45mmol/L和(-14.56±3.42)mmol/L,均低于存活组(P<0.05)。结论:百草枯中毒患者的百草枯含量、肺功能和肾功能指标与其预后密切相关,百草枯含量、血肌酐、血尿素氮、PaCO2、剩余碱可提示患者的存活情况。

Objective：To study the relation between paraquat levels , renal function and lung function in patients with acute paraquat poi-soning and its prognosis .Methods：107 patients with acute paraquat poisoning were studied , were divided into survival group and death group according to the prognosis , paraquat levels , renal function and lung function was detected in the patients .Results：Plasma levels, urine paraquat levels was （9.54 ±1.13,423.23 ±63.43） mg/L in the death group, was higher than that in the survival group .Serum creatinine, blood urea nitrogen, carbon dioxide partial pressure （PaCO2） was （141.8 ±18.2）mmol/L,（11.4 ±2.2）mmol/L and（41.32 ±6.32）mmHg,higher than that in the survival group , pressure of oxygen （PaO2）,actual bicarbonate （PCO3-） and base excess （BE） was（79.44 ±10.42）mmHg,（14.82 ±2.45）mmol/L and（-14.56 ±3.42） mmol/L,lower than that in the survival group （P＆lt;0.05）. Conclusion：The content of paraquat , pulmonary and renal function in the patients with paraquat poisoning have a close relation with its prognosis, paraquat levels, serum creatinine ,blood urea nitrogen, PaCO2 and base excess may prompt the patient＆#39;s survival.