清胞饮对高危型人乳头瘤病毒治疗效果的临床研究

Clinical research on effect of Qing Pinocytosis in the treatment of infection patients with high-risk human papilloma virus

目的探讨清胞饮对官颈内瘤样病变术后高危型人乳头瘤病毒（HPV）治疗效果的临床研究。方法选择2011年9月～2013年9月湖北省十堰市妇幼保健院因宫颈内瘤样病变行Leep术的400例患者．将其分为治疗组和对照组，各200例，治疗组应用清胞饮进行治疗，对照组应用复方黄柏液进行治疗，治疗1、2、4、6个月后对比两组高危型HPV消除率、HPV持续阳性治愈率及转阴率。结果治疗组术后1、2、4、6个月高危型HPV消除率分别为89．00％（178／200）、96．10％（192／200）、97．50％（195／200）、98．60％（198／200）；对照组为56．16％（113／200）、64．5％（129／200）、70．25％（144／200）、79．4％（158／200），差异有统计学意义（P〈0．05）。两组高危型HPV消除效果组内比较，差异均有统计学意义（对照组：χ2=13．009，P〈0．05；治疗组：χ2=25．303，P〈0．01）。治疗组治愈率为98．50％，对照组为79．00％，差异有统计学意义（χ2=10．221，P〈0．05）。治疗组转阴率为75．65％，明显高于对照组（21．00％），差异有高度统计学意义（χ2=11．326，P〈0．01）；且两组总有效率比较，差异有高度统计学意义（96．50％比64．00％，χ2=14．005，P〈0．01）。结论应用清胞饮对术后高危型HPV持续感染治疗效果显著，可为高危型HPV的治疗提供可靠依据，值得深入研究。

Objective To discuss the clinical research of Qing Pinocytosis in the treatment of infection patients with cervical high-risk human papilloma virus （HPV）. Methods 400 cases of women due to cervical within tumor sample le- sions line LeeP surgery from September 2011 to September 2013 in Maternal and Child Health Hospital of Shiyan City in Hubei Province were divided into treatment group and control group, each group had 200 cases, treatment group was applied Qing Pinocytosis for treatment, control group was given Compound Cortex Phellodendri Liquid. The high risk HPV elimination rate, HPV sustained positive rate and negative conversion rate after operation for 1, 2, 4, 6 months be- tween the two groups were compared. Results High-risk HPV eliminating rate of the treatment group after operation for 1, 2, 4, 6 months were 89.00% （178/200）, 96.10% （192/200）, 97.50% （195/200）, 98.60% （198/200）; which of the con- trol group were 56.16% （113/200）, 64.5% （129/200）, 70.25% （144/200）, 79.4% （158/200）, the differences were statisti- cally significant （P 〈 0.05）. Differences of high-risk type HPV elimination effect in the two groups were statistically signif icant （control group： χ2=-13.009, P 〈 0.05; treatment group：χ2=-25.303, P 〈 0.01）. The cure rate in treatment group was 98.50%, which of control group was 79.00%, the difference between the two groups was statistically significant （χ2=10.221, P 〈 0.05）. The negative conversion rate of the treatment group was 75.65%, which was obviously higher than that of control group （21.00%）, the difference was statistically significant （χ2=11.326, P 〈 0.01）; and the difference of total effective rate be- tween the two groups was statistically significant （96.50% vs 64.00%, χ2=14.005, P 〈 0.01）. Conclusion Application of Qing Pinocytosis on the postoperative high-risk type HPV infection is remarkable, which can provide reliable basis for the treatment of high-risk human papilloma virus, which deserves more in-depth study.