荆花胃康胶丸联合三联疗法对Hp补救治疗的疗效对比分析

Treatment effect and eradication rate of patients with helicobacter pylori eradication failure with Jinghua Weikang capsule combined with triple therapy of moxifloxacin

目的观察对幽门螺旋杆菌根除失败患者,用荆花胃康胶丸联合含莫西沙星的三联疗法行补救治疗的效果及根除率。方法入选者为经14C-呼气试验证实为Hp阳性患者56例,至少行幽门螺旋杆菌根除治疗1次以上,所有患者随机分成2组,一组28例予标准三联疗法(克拉霉素+阿莫西林+雷贝拉唑)14 d。另一组28例给予含莫西沙星的三联疗法(莫西沙星+阿莫西林+雷贝拉唑)14 d加口服荆花胃康胶丸;2组治疗结束后,均停药1月后复查14C-呼气试验,比较2组患者的根除幽门螺旋杆菌的疗效及根除率。结果 2组Hp根除率相比较,差异有统计学意义(P<0.05),2组均无严重的副反应,标准三联组Hp根除率74.6%(47/63),而含荆花胃康胶丸及莫西沙星的三联疗法组Hp根除率93.8%(60/64)。结论对幽门螺旋杆菌根除失败患者,给予含莫西沙星的三联疗法加荆花胃康胶丸比标准三联疗法治疗效果更好。

Objective To explore the treatment effect and eradication rate of patients with helicobacter pylori eradication failure with Jinghua Weikang capsule combined with triple therapy of moxifloxacin. Methods Enrolled for confirmed by 14C-breath test for 56 patients with Hp positive,at least received helicobacter pylori eradication therapy more than one time,all the patients were randomly divided into two groups,a group of 28 cases with standard triple therapy（ clarithromycin ＋ amoxicillin ＋ rabeprazole） 14 d. Another group of 28 cases was given triple therapy with moxifloxacin（ moxifloxacin ＋ amoxicillin ＋ rabeprazole） 14 d plus oral JingHua stomach kang capsule; after the treatment,drug withdrawal after 1 month review of14C-breath test and comparison of two groups of patients and curative effect of eradication of helicobacter pylori eradication rates were performed. Results Hp eradicate rates were compared between the two groups,the difference was statistically significant（ P〈0. 05）,two groups had no serious side effects,standard three transmitte Hp eradication rate was 74. 6%（ 47 /63）,and Hp eradicate rate in the triple therapy of moxifloxacin group was 93. 8%（ 60 /64）. Conclusion In patients with helicobacter pylori eradication failure,given with moxifloxacin triple therapy plus JingHua stomach kang capsule was better than the standard triple therapy treatment.