厄贝沙坦氢氯噻嗪联合瑞舒伐他汀治疗原发性高血压伴左心室肥厚的疗效研究

Effect of Irbesartan Hydrochlorothiazide Combined with Rosuvastatin on Essential Hypertension with Left Ventricular Hypertrophy

目的观察厄贝沙坦氢氯噻嗪(安博诺)联合瑞舒伐他汀治疗原发性高血压(EH)伴左室肥厚(LVH)的疗效。方法选取2011年2月—2012年12月我院收治的EH伴LVH患者95例,将其随机分为对照组47例和治疗组48例。对照组常规服用安博诺治疗,治疗组在对照组基础上加用瑞舒伐他汀治疗,两组均治疗6个月。观察治疗前后两组舒张末期室间隔厚度(IVST)、舒张末期左室后壁厚度(PWT)、舒张末期左室内径(LVDd)、左心室质量指数(LVMI)等的变化,并比较不良反应发生情况。结果治疗前两组LVDd、IVST、PWT、LVMI比较,差异均无统计学意义(P>0.05);治疗后治疗组LVDd、IVST、PWT、LVMI均低于对照组(P<0.05)。对照组不良反应发生率为6.4%(3/47),治疗组为4.2%(2/48),两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论安博诺联合瑞舒伐他汀能有效逆转EH患者的LVH,改善左心室功能,较单一用药疗效显著。

Objective To observe the effect of Irbesartan hydrochlorothiazide（ Bonuo） combined with Rosuvastatin on essential hypertrophy（ EH） with left ventricular hypertrophy（ LVH）. Methods 95 patients with EH and LVH admitted to our hospital from February 2011 to December 2012 were randomly divided into groups control（ 47 cases） and treatment（ 48 cases）. Control group was given Bonuo,treatment group was given Rosuvastatin on basis of control group,both treated for 6 months. The IVST,PWT,LVDd,LVMI and incidence of adverse reaction were observed between two groups before and after treatment. Results Before treatment,the LVDd,IVST,PWT,LVMI between two groups showed no significant differences（ P〈0. 05）; after treatment,the LVDd,IVST,PWT,LVMI in treatment group were lower than those of control group（ P〈0. 05）. The incidence of adverse reaction of control group was 6. 4%（ 3 /47）,the treatment group was 4. 2%（ 2 /48）,the incidence of adverse reaction between two groups showed no significant differences（ P〉 0. 05）. Conclusion Bonuo combined with Rosuvastatin can improve the LVH in EH patient,and have a better effect than single drug.