酪酸梭菌活菌散联合葡萄糖酸锌治疗儿童急性腹泻的疗效观察

Curative effect of Clostridium Butyricum Powder combined with Zinc Gluconate on children with acute diarrhea

目的探讨酪酸梭菌活菌散联合葡萄糖酸锌治疗儿童急性腹泻的疗效。方法选取急性腹泻患儿76例,随机分为观察组和对照组各38例。两组患儿均予以调整饮食、口服或静脉补液和纠正水电解质酸碱失衡紊乱等常规治疗。观察组患儿予以酪酸梭菌活菌散和葡萄糖酸锌联合治疗,对照组患儿予以单纯酪酸梭菌活菌散治疗。观察两组患儿治疗后主要症状和体征改善的时间,并比较其临床疗效及治疗后3个月内腹泻的复发率。结果观察组患儿治疗后的止泻、呕吐、腹痛和粪常规等恢复正常时间均明显短于对照组(P<0.05);同时治疗3 d后,观察组患儿临床总有效率为94.74%,明显高于对照组的78.95%(χ2=4.15,P<0.05)。两组患儿治疗后随访3个月,其中观察组和对照组分别腹泻复发5例(13.16%)和13例(34.21%),观察组腹泻的复发率明显低于对照组(χ2=4.66,P<0.05)。结论酪酸梭菌活菌散联合葡萄糖酸锌治疗儿童急性腹泻的疗效较肯定,能明显改善患儿腹泻症状,缩短腹泻病程,并能减少腹泻的复发。

Objective To discuss the curative effect of Clostridium Butyricum Powder combined with Zinc Gluconate （ZNG） on children with acute diarrhea. Methods 76 cases of children with acute diarrhea were selected and divided into observation group and control group at random, with 38 cases of children in each group. Both groups were given routine medical treatment, including diet adjustment, oral and intravenous fluid infusion, adjustment of disturbance of water electrolyte and acid-base imbalance etc.. The children in observation group were given combined medical treatment of Clostridium Butyricum Powder and ZNG, while the children in control group were only given Clostridium Butyricum Powder. The significant symptoms and time to physical improvement after the medical treatment were observed, and clinical curative effect and reoccurrence rate of diarrhea within 3 months after the medical treatment were compared. Results The times to recovery of diarrhea, vomit, abdominalgia and stool ete of children in observation group were much shorter than those in control group （ P 〈 0.05 ）. After 3 days＇ medical treatment, the total clinical efficiency of children in observation group was 94.74%, which was much higher than that in control group （78.95%） （X2 =4.15, P 〈 0.05）. After 3 months＇ follow-up, 5 and 13 cases of diarrhea reoccurred in observation group （13.16%）and control group （34.21%） respectively, with the reoccurrence rate in observation group much lower than that in control group （X2 = 4.66, P 〈 0.05）. Conclusion Clostridium Butyrieum Powder combined with ZNG has confirmative curative effect on children with acute diarrhea, which can obviously improve the diarrhea symptoms, shorten the course of disease and reduce the reoccurrence of diarrhea.